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Evaluation of the regional cerebral blood flow changes during long-term donepezil therapy in patients with Alzheimer’s disease using 3DSRT


Kimura, Noriyuki, Kumamoto, Toshihide, Masuda, Teruaki, Hanaoka, Takuya, Okazaki, Toshio, Arakawa, Ryuki


Journal Of Neuroimaging: Official Journal Of The American Society Of Neuroimaging, Volume: 22, No.: 3, Pages.: 299-304

Year of Publication



Background: We attempt to evaluate objectively the regional cerebral blood flow (rCBF) changes during long-term donepezil therapy and the relationship between the clinical response and rCBF change in patients with Alzheimer’s disease (AD).; Patients and Methods: Thirty-one patients with mild-to-moderate AD (11 men, 20 female; mean age, 76.2 ± 6.7 years) were treated with donepezil and underwent brain perfusion single-photon emission computed tomography (SPECT) twice with an interval of 24.5 ± 4.2 months. The rCBF was calculated using 3-dimensional stereotaxic region of interest template, a fully automated each region of interest technique. We compared the differences in rCBF between baseline and follow-up SPECT studies. Moreover, all patients were divided into stabilized (n = 14) and nonstabilized subgroups (n = 17) based on Mini-Mental State Examination (MMSE) score changes and the changes in rCBF were compared between two subgroups.; Results: The mean MMSE score significantly decreased from 20.7 ± 4.6 at baseline to 16.5 ± 6.5 after 2 years. The mean rCBF significantly decreased in the widespread brain regions between the baseline and follow-up SPECT studies. The nonstabilized subgroup showed a significant decrease in rCBF of the parietal and temporal segments compared to the stabilized subgroup.; Conclusion: The progression of cognitive deterioration may be related to rCBF affected by the neuropathologic changes of AD.; © 2011 by the American Society of Neuroimaging.

Bibtex Citation

@article{Kimura_2011, doi = {10.1111/j.1552-6569.2011.00612.x}, url = {}, year = 2011, month = {jun}, publisher = {Wiley-Blackwell}, volume = {22}, number = {3}, pages = {299--304}, author = {Noriyuki Kimura and Toshihide Kumamoto and Teruaki Masuda and Takuya Hanaoka and Toshio Okazaki and Ryuki Arakawa}, title = {Evaluation of the Regional Cerebral Blood Flow Changes during Long-Term Donepezil Therapy in Patients with Alzheimer{textquotesingle}s Disease Using 3DSRT}, journal = {Journal of Neuroimaging} }


administration & dosage, aged, aged, 80 and over, alzheimer disease, blood, blood flow velocity, cerebral, cerebrovascular circulation, donepezil, drug effects, drug therapy, female, flow, humans, imaging threedimensional, indans, longitudinal studies, male, middle aged, nootropic agents, physiopathology, piperidines, radionuclide imaging, tomography emissioncomputed singlephoton, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes

Cognition, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime