This database contains 477 studies, archived under the term: "Non-pharmacological Treatment"
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Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial)
Ballard, Clive,
Brown, Richard,
Fossey, Jane,
Douglas, Simon,
Bradley, Paul,
Hancock, Judith,
James, Ian A.,
Juszczak, Edmund,
Bentham, Peter,
Burns, Alistair,
Lindesay, James,
Jacoby, Robin,
O'Brien, John,
Bullock, Roger,
Johnson, Tony,
Holmes, Clive,
Howard, Robert
Background: Good practice guidelines state that a psychological intervention should usually precede pharmacotherapy, but there are no data evaluating the feasibility of psychological interventions used in this way. Methods: At the first stage of a randomized blinded placebo-controlled trial, 318 patients with Alzheimer disease (AD) with clinically significant agitated behavior were treated in an open […]
Effects of a controlled trial of aerobic exercise for mild cognitive impairment: A controlled trial
Baker, Laura D.,
Frank, Laura L.,
Foster-Schubert, Karen,
Green, Pattie S.,
Wilkinson, Charles W.,
McTiernan, Anne,
Plymate, Stephen R.,
Fishel, Mark A.,
Watson, G. Stennis,
Cholerton, Brenna A.,
Dunca, Glen E.,
Mehta, Pankaj D.,
Craft, Suzanne
Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. Design: Six-month, randomized, controlled, clinical trial. Setting: Veterans Affairs Puget Sound Health Care System clinical research unit. Participants: Thirty-three […]
Randomized controlled trial of a Healthy Brain Ageing Cognitive Training program: Effects on memory, mood, and sleep
Diamond, Keri,
Mowszowski, Loren,
Cockayne, Nicole,
Norrie, Louisa,
Paradise, Matthew,
Hermens, Daniel F.,
Lewis, Simon J. G.,
Hickie, Ian B.,
Naismith, Sharon L.
Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]
Mild cognitive impairment disease treated with electroacupuncture: a multi-center randomized controlled trial
Zhao, Ling,
Zhang, Fu-Wen,
Zhang, Hong,
Zhao, Yu,
Zhou, Bo,
Chen, Wei-Yin,
Zhu, Man-Jia
Objective: To verify the clinical efficacy on mild cognitive impairment (MCI) treated with electroacupuncture (EA) intervention based on the principle as “promoting the circulation of the Governor Vessel and regulating the marrow” and plan to provide the A-grade evidence of the evidence-based medicine for the clinical treatment of this disease with acupuncture and moxibustion.; Methods: […]
FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
Feng, Yuanyuan,
Bai, Lijun,
Ren, Yanshuang,
Chen, Shangjie,
Wang, Hu,
Zhang, Wensheng,
Tian, Jie
The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer’s disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the […]
Preventing disruptive behavior of nursing home residents
Disruptive behavior is an increasing challenge for professional care in nursing homes. It frequently accompanies dementia, which is one of the most common chronic illnesses among the residents. Nursing homes are, therefore, subject to a high accumulation of problems due to behavior with risk potential. However, usual nursing interventions are often limited to restrictions in […]
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
Weaver, Frances M.,
Follett, Kenneth A.,
Stern, Matthew,
Luo, Ping,
Harris, Crystal L.,
Hur, Kwan,
Marks, William J., Jr.,
Rothlind, Johannes,
Sagher, Oren,
Moy, Claudia,
Pahwa, Rajesh,
Burchiel, Kim,
Hogarth, Penelope,
Lai, Eugene C.,
Duda, John E.,
Holloway, Kathryn,
Samii, Ali,
Horn, Stacy,
Bronstein, Jeff M.,
Stoner, Gatana,
Starr, Philip A.,
Simpson, Richard,
Baltuch, Gordon,
De Salles, Antonio,
Huang, Grant D.,
Reda, Domenic J.
Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]
Efficacy of psychosocial intervention in patients with mild Alzheimer’s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY)
Waldorff, F. B.,
Buss, D. V.,
Eckermann, A.,
Rasmussen, M. L. H.,
Keiding, N.,
Rishøj, S.,
Siersma, V.,
Sørensen, J.,
Sørensen, L. V.,
VOGEL, A.,
WALDEMAR, G.
Objective: To assess the efficacy at 12 months of an early psychosocial counselling and support programme for outpatients with mild Alzheimer’s disease and their primary care givers.; Design: Multicentre, randomised, controlled, rater blinded trial.; Setting: Primary care and memory clinics in five Danish districts.; Participants: 330 outpatients with mild Alzheimer’s disease and their 330 primary […]