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Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes


Weaver, Frances M., Follett, Kenneth A., Stern, Matthew, Luo, Ping, Harris, Crystal L., Hur, Kwan, Marks, William J., Jr., Rothlind, Johannes, Sagher, Oren, Moy, Claudia, Pahwa, Rajesh, Burchiel, Kim, Hogarth, Penelope, Lai, Eugene C., Duda, John E., Holloway, Kathryn, Samii, Ali, Horn, Stacy, Bronstein, Jeff M., Stoner, Gatana, Starr, Philip A., Simpson, Richard, Baltuch, Gordon, De Salles, Antonio, Huang, Grant D., Reda, Domenic J.


Neurology, Volume: 79, No.: 1, Pages.: 55-65

Year of Publication



Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. The primary outcome was motor function on stimulation/off medication using the Unified Parkinson’s Disease Rating Scale motor subscale. Secondary outcomes included quality of life and neurocognitive function.; Results: Motor function improved between baseline and 36 months for GPi (41.1 to 27.1; 95% confidence interval [CI] -16.4 to -10.8; p < 0.001) and STN (42.5 to 29.7; 95% CI -15.8 to -9.4; p < 0.001); improvements were similar between targets and stable over time (p = 0.59). Health-related quality of life improved at 6 months on all subscales (all p values significant), but improvement diminished over time. Mattis Dementia Rating Scale scores declined faster for STN than GPi patients (p = 0.01); other neurocognitive measures showed gradual decline overall.; Conclusions: The beneficial effect of DBS on motor function was stable and comparable by target over 36 months. Slight declines in quality of life following initial gains and gradual decline in neurocognitive function likely reflect underlying disease progression and highlight the importance of nonmotor symptoms in determining quality of life.; Classification Of Evidence: This study provides Class III evidence that improvement of motor symptoms of PD by DBS remains stable over 3 years and does not differ by surgical target. Neurology® 2012;79:55-65.;

Bibtex Citation

@article{Weaver_2012, doi = {10.1212/wnl.0b013e31825dcdc1}, url = {}, year = 2012, month = {jun}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {79}, number = {1}, pages = {55--65}, author = {F. M. Weaver and K. A. Follett and M. Stern and P. Luo and C. L. Harris and K. Hur and W. J. Marks and J. Rothlind and O. Sagher and C. Moy and R. Pahwa and K. Burchiel and P. Hogarth and E. C. Lai and J. E. Duda and K. Holloway and A. Samii and S. Horn and J. M. Bronstein and G. Stoner and P. A. Starr and R. Simpson and G. Baltuch and A. De Salles and G. D. Huang and D. J. Reda}, title = {Randomized trial of deep brain stimulation for Parkinson disease: Thirty-six-month outcomes}, journal = {Neurology} }


aged, brain, deep, deep brain stimulation, female, followup studies, humans, male, methods, middle aged, motor skills, parkinson disease, physiology, physiopathology, prospective studies, psychology, quality of life, singleblind method, stimulation, therapy, treatment outcome

Countries of Study


Types of Dementia

Parkinson’s Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

Cognition, Quality of Life of Person With Dementia

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions