Jiang, Changchuan, Xu, Yong

Objectives: The ability to perform instrumental activities of daily living (IADL) is thought to be relatively intact for people with mild cognitive impairment (MCI). Doing housework as part of IADL is an important skill needed for older people to live independently and successfully. A limited number of studies explore the association between MCI and doing […]

Tate, Judith A., Snitz, Beth E., Alvarez, Karina A., Nahin, Richard L., Weissfeld, Lisa A., Lopez, Oscar, Angus, Derek C., Shah, Faraaz, Ives, Diane G., Fitzpatrick, Annette L., Williamson, Jeffrey D., Arnold, Alice M., DeKosky, Steven T., Yende, Sachin

Objectives: Severe infections, often requiring ICU admission, have been associated with persistent cognitive dysfunction. Less severe infections are more common and whether they are associated with an increased risk of dementia is unclear. We determined the association of pneumonia hospitalization with risk of dementia in well-functioning older adults.; Design: Secondary analysis of a randomized multicenter […]

Sabia, Séverine, Elbaz, Alexis, Dugravot, Aline, Head, Jenny, Shipley, Martin, Hagger-Johnson, Gareth, Kivimaki, Mika, Singh-Manoux, Archana

Context: Smoking is a possible risk factor for dementia, although its impact may have been underestimated in elderly populations because of the shorter life span of smokers.; Objective: To examine the association between smoking history and cognitive decline in the transition from midlife to old age.; Design: Cohort study.; Setting: The Whitehall II study. The […]

Rinne, Juha O., Frantzen, Janek, Leinonen, Ville, Lonnrot, Kimmo, Laakso, Aki, Virtanen, Kirsi A., Solin, Olof, Kotkansalo, Anna, Koivisto, Anne, Sajanti, Juha, Karppinen, Atte, Lehto, Hanna, Rummukainen, Jaana, Buckley, Chris, Smith, Adrian, Jones, Paul A., Sherwin, Paul, Farrar, Gill, McLain, Richard, Kailajarvi, Marita, Grachev, Igor D.

Unlabelled: BACKGOUND/OBJECTIVE: To determine the level of association between uptake of the amyloid positron emission tomography (PET) imaging agent [(18)F]flutemetamol and the level of amyloid-β measured by immunohistochemical and histochemical staining in a frontal cortical region biopsy site.; Methods: Seventeen patients with probable normal pressure hydrocephalus (NPH) underwent prospective [(18)F]flutemetamol PET and subsequent frontal cortical […]

de Rotrou, Jocelyne, Cantegreil, Inge, Faucounau, Véronique, Wenisch, Emilie, Chausson, Catherine, Jegou, David, Grabar, Sophie, Rigaud, Anne-Sophie

Objective: The Aide dans la Maladie d’Alzheimer (AIDMA) study was conducted to determine whether a psycho-educational programme (PEP) for primary caregivers in addition to standard anti-dementia drugs for patients improves caregivers’ psychological condition and patients’ activities of daily life.; Method: Multicentre randomised controlled intervention trial. One hundred and sixty-seven dyads ‘patient-caregiver’ were recruited from 15 […]