This database contains 142 studies, archived under the term: "Non randomised controlled trial"
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Efectos del entrenamiento en estrategias de regulación emocional en el bienestar de cuidadores de enfermos de Alzheimer. = Effects of training in emotional regulation strategies on the well-being of carers of Alzheimer patients
Arritxabal, Igone Etxeberria,
Soler, Álvaro García,
Da Silva, Ainhoa Iglesias,
Artola, Elena Urdaneta,
González, Idoia Lorea,
Veiga, Pura Díaz,
Yanguas Lezaun, José Javier
Introduction; The present research shows the results of a psychoeducational Intervention programme centered on the regulation of the emotion among Alzheimer patients’ caregivers. Materials and methods: 52 informal caregivers of Alzheimer’s patients participated. These caregivers were distributed into two groups: the experimental group (n = 20) and the control group (n = 32). All the […]
Effects of telmisartan on the level of Aβ1-42, interleukin-1β, tumor necrosis factor α and cognition in hypertensive patients with Alzheimer’s disease
Li, Wei,
Zhang, Jie-Wen,
Lu, Fen,
Ma, Ming-Ming,
Wang, Jiang-qiao,
Suo, Ai-Qin,
Bai, Ying-ying,
Liu, Hui-qin
Objective: To explore the effects of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor γ-stimulating activity, on the levels of Aβ1-42, interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) and cognition in elderly hypertensive patients with Alzheimer’s disease (AD).; Methods: A total of 48 patients with probable AD and essential hypertension were randomly […]
The effects of ramipril in individuals at risk for Alzheimer’s disease: results of a pilot clinical trial
Wharton, Whitney,
Stein, James H.,
Korcarz, Claudia,
Sachs, Jane,
Olson, Sandra R.,
Zetterberg, Henrik,
Dowling, Maritza,
Ye, Shuyun,
Gleason, Carey E.,
Underbakke, Gail,
Jacobson, Laura E.,
Johnson, Sterling C.,
Sager, Mark A.,
Asthana, Sanjay,
Carlsson, Cynthia M.
Research shows that certain antihypertensives taken during midlife confer Alzheimer’s disease (AD) related benefits in later life. We conducted a clinical trial to evaluate the extent to which the angiotensin converting enzyme inhibitor (ACE-I), ramipril, affects AD biomarkers including cerebrospinal fluid (CSF) amyloid-β (Aβ) levels and ACE activity, arterial function, and cognition in participants with […]
A community-based approach to trials of aerobic exercise in aging and Alzheimer’s disease
Vidoni, Eric D.,
Van Sciver, Angela,
Johnson, David K.,
He, Jinghua,
Honea, Robyn,
Haines, Brian,
Goodwin, Jami,
Laubinger, M. Pat,
Anderson, Heather S.,
Kluding, Patricia M.,
Donnelly, Joseph E.,
Billinger, Sandra A.,
Burns, Jeffrey M.
The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. […]
Dementelcoach: effect of telephone coaching on carers of community-dwelling people with dementia
Background: Dementelcoach is a new telephone intervention to support informal caregivers of community dwelling people with dementia. The effectiveness of this intervention was evaluated on burden and mental health problems of informal caregivers.; Methods: A pre-test/post-test comparison group design was used with three groups of informal caregivers.Two of the groups were experimental and received either […]
Does theatre improve the quality of life of people with dementia?
Background: A new communication method, the “Veder method”, has recently been developed. Caregivers are trained to apply this method in a group activity (“living-room theatre activity”) for people with dementia in which theatrical stimuli are used in combination with proven emotion-oriented care methods. The aim of this exploratory study was to evaluate the added value […]
Pilot study of granulocyte-colony stimulating factor for treatment of Alzheimer’s disease
Sanchez-Ramos, Juan,
Cimino, Cynthia,
Avila, Ross,
Rowe, Amanda,
Chen, Ren,
Whelan, Glenn,
Lin, Xiaoyang,
Cao, Chuanhai,
Ashok, Raj
Human granulocyte colony-stimulating-factor (G-CSF) is widely used for treatment of neutropenia and to mobilize stem/progenitor cells for bone marrow transplantation. In studies of thousands of healthy donor subjects treated with G-CSF to mobilize stem/progenitor cells, the side-effect profile has been reported to be mild and reversible. In pre-clinical studies, G-CSF was reported to improve spatial […]