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A community-based approach to trials of aerobic exercise in aging and Alzheimer’s disease


Vidoni, Eric D., Van Sciver, Angela, Johnson, David K., He, Jinghua, Honea, Robyn, Haines, Brian, Goodwin, Jami, Laubinger, M. Pat, Anderson, Heather S., Kluding, Patricia M., Donnelly, Joseph E., Billinger, Sandra A., Burns, Jeffrey M.


Contemporary Clinical Trials, Volume: 33, No.: 6, Pages.: 1105-1116

Year of Publication



The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. Demonstrating that aerobic exercise alters the AD process would have enormous public health implications. The purpose of this paper is to report the protocol of a current, community-based pilot study of aerobic exercise for AD to guide future investigation. This manuscript provides 1) an overview of possible benefits of exercise in those with dementia, 2) a rationale and recommendations for implementation of a community-based approach, 3) recommendation for implementation of similar study protocols, and 4) unique challenges in conducting an exercise trial in AD.; Copyright © 2012 Elsevier Inc. All rights reserved.

Bibtex Citation

@article{Vidoni_2012, doi = {10.1016/j.cct.2012.08.002}, url = {}, year = 2012, month = {nov}, publisher = {Elsevier {BV}}, volume = {33}, number = {6}, pages = {1105--1116}, author = {Eric D. Vidoni and Angela Van Sciver and David K. Johnson and Jinghua He and Robyn Honea and Brian Haines and Jami Goodwin and M. Pat Laubinger and Heather S. Anderson and Patricia M. Kluding and Joseph E. Donnelly and Sandra A. Billinger and Jeffrey M. Burns}, title = {A community-based approach to trials of aerobic exercise in aging and Alzheimer{textquotesingle}s disease}, journal = {Contemporary Clinical Trials} }


aged, aging, alzheimer disease, cognition, communitybased participatory research, exercise, female, humans, male, middle aged, organization administration, physiology, physiopathology, pilot projects, prevention & control

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Non randomised controlled trial



Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Exercise (inc. dancing)