This database contains 19 studies, archived under the term: "Epidemiological"
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Midlife cardiovascular risk factors and late cognitive impairment
Virta, Jyri J.,
Heikkilä, Kauko,
Perola, Markus,
Koskenvuo, Markku,
Räihä, Ismo,
Rinne, Juha O.,
Kaprio, Jaakko
Cardiovascular risk factors increase the risk of dementia in later life. The aims of the current study were to assess the effect of multiple midlife cardiovascular risk factors on the risk of cognitive impairment in later life, and to assess the validity of the previously suggested CAIDE Study risk score predicting dementia risk 20 years later. […]
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study
Shatunov, Aleksey,
Mok, Kin,
Newhouse, Stephen,
Weale, Michael E,
Smith, Bradley,
Vance, Caroline,
Johnson, Lauren,
Veldink, Jan H,
van Es, Michael A,
van den Berg, Leonard H.,
Robberecht, Wim,
Van Damme, Philip,
Hardiman, Orla,
Farmer, Anne E,
Lewis, Cathryn M,
Butler, Amy W,
Abel, Olubunmi,
Andersen, Peter M,
Fogh, Isabella,
Silani, Vincenzo,
Chiò, Adriano,
Traynor, Bryan J,
Melki, Judith,
Meininger, Vincent,
Landers, John E,
McGuffin, Peter,
Glass, Jonathan D,
Pall, Hardev,
Leigh, P Nigel,
Hardy, John,
Brown, Robert H,
Powell, John F,
Orrell, Richard W,
Morrison, Karen E,
Shaw, Pamela J,
Shaw, Christopher E,
Al-Chalabi, Ammar
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons that results in progressive weakness and death from respiratory failure, commonly within about 3 years. Previous studies have shown association of a locus on chromosome 9p with ALS and linkage with ALS-frontotemporal dementia. We aimed to test whether this genomic region is also […]
Relation of hemoglobin to level of cognitive function in older persons
Shah, Raj C.,
Wilson, Robert S.,
Tang, Yuxiao,
Dong, Xinqi,
Murray, Anne,
Bennett, David A.
Background: While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood.; Methods: Cross-sectional analyses were conducted utilizing data from community-dwelling, older persons participating in the Rush Memory and Aging Project. Proximate to first available hemoglobin measurement, 21 cognitive tests were […]
Japanese-English language equivalence of the Cognitive Abilities Screening Instrument among Japanese-Americans
Gibbons, Laura E.,
McCurry, Susan,
Rhoads, Kristoffer,
Masaki, Kamal,
White, Lon,
Borenstein, Amy R.,
Larson, Eric B.,
Crane, Paul K.
Background: The Cognitive Abilities Screening Instrument (CASI) was designed for use in cross-cultural studies of Japanese and Japanese-American elderly in Japan and the U.S.A. The measurement equivalence in Japanese and English had not been confirmed in prior studies.; Methods: We analyzed the 40 CASI items for differential item functioning (DIF) related to test language, as […]
The effect of midlife physical activity on cognitive function among older adults: AGES–Reykjavik Study
Chang, M.,
Jonsson, P. V.,
Snaedal, J.,
Bjornsson, S.,
Saczynski, J. S.,
Aspelund, T.,
Eiriksdottir, G.,
Jonsdottir, M. K.,
Lopez, O. L.,
Harris, T. B.,
Gudnason, V.,
Launer, L. J.
Background: There are few studies on the long-term associations of physical activity (PA) to cognition. Here, we examine the association of midlife PA to late-life cognitive function and dementia.; Methods: The sample consisted of a population-based cohort of men and women (born in 1907-1935) participating in the Age Gene/Environment Susceptibility-Reykjavik Study. The interval between the […]
Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins
Brommelhoff, Jessica A.,
Gatz, Margaret,
Johansson, Boo,
McArdle, John J.,
Fratiglioni, Laura,
Pedersen, Nancy L.
This study tested whether history of depression is associated with an increased likelihood of dementia, and whether a first depressive episode earlier in life is associated with increased dementia risk, or whether only depressive episodes close in time to dementia onset are related to dementia. Depression information came from national hospital discharge registries, medical history, […]