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This database contains 384 studies, archived under the term: "Other"

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Neuroimaging predictors of brain amyloidosis in mild cognitive impairment

Objective: To identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid-free.; Methods: The prediction model cohort included 62 MCI subjects screened with structural magnetic resonance imaging (MRI) and (11) […]

MRI sequence findings in sporadic Creutzfeldt-Jakob disease

MRI has had an important role in the diagnosis of Creutzfeldt-Jakob disease (CJD). The aim of our study was to compare the efficacy of different MRI sequences among six biopsy-proven patients with sporadic CJD (sCJD) and seven patients with probable sCJD. These 13 patients with CJD aged from 36 years to 75 years (mean age: […]

Staff training in assisted living: evaluating treatment fidelity

Objectives: To investigate a protocol for identifying and evaluating treatment fidelity in Staff Training in Assisted-living Residences (STAR), a structured but flexible program to train direct care staff to improve care of residents with dementia.; Design: Multisite feasibility trial.; Setting: Assisted living facilities (ALFs).; Participants: Forty-four direct care staff and 36 leadership staff.; Intervention: STAR […]

Perseverative errors on the Wisconsin Card Sorting Test and brain perfusion imaging in mild Alzheimer’s disease

Background: The Wisconsin Card Sorting Test (WCST) has long been used to investigate deficits in executive function in humans. The majority of studies investigating deficient WCST performance focused on the number of categories achieved (CA) and the number of perseverative errors of the Nelson type (PEN). However, there is insufficient evidence that these two measures […]

Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study

Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]

The effects of group living homes on older people with dementia: a comparison with traditional nursing home care

Objectives: The aim of this study was to investigate the effects of group living homes on quality of life and functioning of people with dementia.; Methods: The study had a quasi-experimental design with a baseline measurement on admission and an effect measurement six months later. Participants were 67 residents in 19 group living homes and […]

Testosterone effect on brain metabolism in elderly patients with Alzheimer’s disease: comparing two cases at different disease stages

Objective: To describe the effect of testosterone replacement therapy (TRT) on the brain activity of two demented, hypogonadal male patients with early and late-stage Alzheimer’s disease (AD), respectively.; Methods: We describe the clinical and positron emission tomography (PET) findings for two individuals, one with early stage and the other with late-stage Alzheimer’s disease, before and […]

Reliability and validity of A Quick Test of Cognitive Speed for detecting early-stage dementia in elderly Japanese

Aim: The aim of this study was to evaluate the reliability and validity of A Quick Test of Cognitive Speed (AQT) for detecting early-stage dementia in the elderly Japanese population.; Methods: A total of 280 clinical participants (180 with mild Alzheimer’s disease, 43 with amnestic mild cognitive impairment, 32 with non-amnestic mild cognitive impairment and […]

Feasibility, safety and preliminary evidence of the effectiveness of a home-based exercise programme for older people with Alzheimer’s disease: a pilot randomized controlled trial

Objective: To evaluate the feasibility and safety of a home-based exercise programme for people with Alzheimer’s disease, and to provide preliminary evidence of programme effectiveness in improving balance and mobility and reducing falls risk.; Design: A randomized controlled trial.; Setting: Community.; Participants: Forty people with mild to moderate Alzheimer’s disease (mean age 81.9, SD 5.72; […]

Life review and life story books for people with mild to moderate dementia: a randomised controlled trial

Objectives: To evaluate the effect of different pathways for developing a life story book (LSB) for people with dementia.; Method: Preliminary randomised control trial; 23 people with dementia in care homes (mean age 86) randomly assigned to receive either 12 individual life review sessions and co-creating a LSB or a personal LSB created by their […]

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