This database contains 136 studies, archived under the term: "Carer Burden (instruments measuring burden)"
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The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer’s disease
Cyarto, Elizabeth V.,
Cox, Kay L.,
Almeida, Osvaldo P.,
Flicker, Leon,
Ames, David,
Byrne, Gerard,
Hill, Keith D.,
Beer, Christopher D.,
LoGiudice, Dina,
Appadurai, Kana,
Irish, Muireann,
Renehan, Emma,
Lautenschlager, Nicola T.
Background: Observational studies have documented a potential protective effect of physical exercise in older adults who are at risk for developing Alzheimer’s disease. The Fitness for the Ageing Brain II (FABS II) study is a multicentre randomized controlled clinical trial (RCT) aiming to determine whether physical activity reduces the rate of cognitive decline among individuals […]
Health and nutritional promotion program for patients with dementia (NutriAlz Study): design and baseline data
Salva, A.,
Andrieu, S.,
Fernandez, E.,
Schiffrin, E. J.,
Moulin, J.,
Decarli, B.,
Guigoz, Y.,
Vellas, B.
Background: There is a lack of data on global weight loss prevention programs for patients with dementia or clear evidence about their impact on a functional level, caregiver burden or the use of healthcare and social resources. NutriAlz is a socio-educative and nutritional intervention program to prevent weight loss and loss of function in dementia […]
Cost-effectiveness of post-diagnosis treatment in dementia coordinated by Multidisciplinary Memory Clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial
Meeuwsen, E. J.,
German, P.,
Melis, R. J. F.,
Adang, E. M.,
Golüke-Willemse, G. A.,
Krabbe, P. F.,
de Leest, B. J.,
van Raak, F. H. J. M.,
Schölzel-Dorenbos, C. J. M.,
Visser, M. C.,
Wolfs, C. A.,
Vliek, S.,
Rikkert, M. G. M. Olde
Background: With the rising number of dementia patients with associated costs and the recognition that there is room for improvement in the provision of dementia care, the question arises on how to efficiently provide high quality dementia care.; Objective: To describe the design of a study to determine multidisciplinary memory clinics’ (MMC) effectiveness and cost-effectiveness […]
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer’s disease – a multicentre RCT
Jones, Rob,
Sheehan, Bart,
Phillips, Patrick,
Juszczak, Ed,
Adams, Jessica,
Baldwin, Ashley,
Ballard, Clive,
Banerjee, Sube,
Barber, Bob,
Bentham, Peter,
Brown, Richard,
Burns, Alistair,
Dening, Tom,
Findlay, David,
Gray, Richard,
Griffin, Mary,
Holmes, Clive,
Hughes, Alan,
Jacoby, Robin,
Johnson, Tony,
Jones, Roy,
Knapp, Martin,
Lindesay, James,
McKeith, Ian,
McShane, Rupert,
Macharouthu, Ajay,
O'Brien, John,
Onions, Caroline,
Passmore, Peter,
Raftery, James,
Ritchie, Craig,
Howard, Rob
Background: Alzheimer’s disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has been widely prescribed, often in the later stages of AD. Memantine is licensed for moderate to severe dementia […]
Dementia care initiative in primary practice: study protocol of a cluster randomized trial on dementia management in a general practice setting
Holle, Rolf,
Grässel, Elmar,
Ruckdäschel, Stefan,
Wunder, Sonja,
Mehlig, Hilmar,
Marx, Peter,
Pirk, Olaf,
Butzlaff, Martin,
Kunz, Simone,
Lauterberg, Jörg
Background: Current guidelines for dementia care recommend the combination of drug therapy with non-pharmaceutical measures like counselling and social support. However, the scientific evidence concerning non-pharmaceutical interventions for dementia patients and their informal caregivers remains inconclusive. Targets of modern comprehensive dementia care are to enable patients to live at home as long and as independent […]
Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer’s disease: protocol for a randomised trial
Hill, Keith D.,
LoGiudice, Dina,
Lautenschlager, Nicola T.,
Said, Catherine M.,
Dodd, Karen J.,
Suttanon, Plaiwan
Background: Balance dysfunction and falls are common problems in later stages of dementia. Exercise is a well-established intervention to reduce falls in cognitively intact older people, although there is limited randomised trial evidence of outcomes in people with dementia. The primary objective of this study is to evaluate whether a home-based balance exercise programme improves […]
Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice
Hayashi, Yoshihito,
Ishida, Yasushi,
Inoue, Teruhiko,
Udagawa, Mitsutaka,
Takeuchi, Kouzou,
Yoshimuta, Hirofumi,
Kiue, Kouichirou,
Ninomiya, Yoshimasa,
Kawano, Jiro,
Sameshima, Tetsuro,
Kawahara, Takashi,
Goto, Isamu,
Shudo, Kenji,
Kurayama, Shigeki,
Nakamura, Jungo,
Okahara, Kazunori,
Mitsuyama, Yoshio
The efficacy and safety of the kampo medicine Yokukansan (YKS, TJ-54) in the treatment of behavioral and psychological symptoms of dementia (BPSD) were investigated in patients with Alzheimer’s disease (AD) in an open-label study. This study included 26 patients who had been diagnosed as having AD and were not treated with donepezil hydrochloride. These patients […]