This database contains 250 studies, archived under the term: "Mild Cognitive Impairment (MCI)"
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Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial
Suzuki, Takao,
Shimada, Hiroyuki,
Makizako, Hyuma,
Doi, Takehiko,
Yoshida, Daisuke,
Tsutsumimoto, Kota,
Anan, Yuya,
Uemura, Kazuki,
Lee, Sangyoon,
Park, Hyuntae
Background: To examine the effects of a multicomponent exercise program on the cognitive function of older adults with amnestic mild cognitive impairment (aMCI).; Design: Twelve months, randomized controlled trial;; Setting: Community center in Japan;; Participants: Fifty older adults (27 men) with aMCI ranging in age from 65 to 93 years (mean age, 75 years);; Intervention: […]
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, Natalie,
Milte, Catherine M.,
Street, Steven J.,
Buckley, Jonathan D.,
Coates, Alison M.,
Petkov, John,
Howe, Peter R.C.
Depressive symptoms may increase the risk of progressing from mild cognitive impairment (MCI) to dementia. Consumption of n-3 PUFA may alleviate both cognitive decline and depression. The aim of the present study was to investigate the benefits of supplementing a diet with n-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and […]
DNA methylation and cognitive functioning in healthy older adults
Schiepers, Olga J. G.,
van Boxtel, Martin P. J.,
de Groot, Renate H. M.,
Jolles, Jelle,
Kok, Frans J.,
Verhoef, Petra,
Durga, Jane
Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status […]
Mild to moderate cognitive impairment is a major risk factor for mortality and nursing home admission in the first year after hip fracture
Schaller, F.,
Sidelnikov, E.,
Theiler, R.,
Egli, A.,
Staehelin, H. B.,
Dick, W.,
Dawson-Hughes, B.,
Grob, D.,
Platz, A.,
Can, U.,
Bischoff-Ferrari, H. A.
Background: It is not well established if and to what extent mild to moderate cognitive impairment predicts mortality and risk of nursing home admission after hip fracture.; Objective: To investigate prospectively whether and to what extent mild to moderate cognitive impairment, contributes to mortality and admission to nursing home in the first year after acute […]
Hormone levels and cognitive function in postmenopausal midlife women
Ryan, Joanne,
Stanczyk, Frank Z.,
Dennerstein, Lorraine,
Mack, Wendy J.,
Clark, Margaret S.,
Szoeke, Cassandra,
Kildea, Daniel,
Henderson, Victor W.
Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women’s Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, […]
Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment
Rondanelli, Mariangela,
Opizzi, Annalisa,
Faliva, Milena,
Mozzoni, Marco,
Antoniello, Neldo,
Cazzola, Roberta,
Savarè, Rita,
Cerutti, Renata,
Grossi, Enzo,
Cestaro, Benvenuto
Age-related changes in nutritional status can play an important role in brain functioning. Specific nutrient deficiencies in the elderly may exacerbate pathological processes in the brain. Consequently, the potential of nutritional intervention to prevent or delay cognitive impairment and the development of dementia is an important topic. A randomized, double-blind, placebo-controlled trial has been performed […]
An inpatient rehabilitation model of care targeting patients with cognitive impairment
McGilton, Katherine S.,
Davis, Aileen,
Mahomed, Nizar,
Flannery, John,
Jaglal, Susan,
Cott, Cheryl,
Naglie, Gary,
Rochon, Elizabeth
Background: The course and outcomes of hip fracture patients are often complicated by the presence of dementia and delirium, referred to as cognitive impairment (CI), which limits access to in-patient rehabilitation. In response to this concern, members of our team developed and piloted an in-patient rehabilitation model of care (Patient-Centred Rehabilitation Model; PCRM) targeting patients […]
Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial
Makizako, Hyuma,
Doi, Takehiko,
Shimada, Hiroyuki,
Yoshida, Daisuke,
Tsutsumimoto, Kota,
Uemura, Kazuki,
Suzuki, Takao
Background and Aims: There has been much interest in exercise interventions as a primary behavioral prevention strategy against cognitive decline. The aim of this study was to evaluate the effect of a multicomponent exercise program on physical and dual-task performances in community-dwelling older adults with amnestic mild cognitive impairment (aMCI).; Methods: Fifty older adults (23 […]