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This database contains 250 studies, archived under the term: "Mild Cognitive Impairment (MCI)"

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Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
Context: The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning.; Objective: To determine whether G. biloba slows the rates of global or domain-specific cognitive decline in older adults.; Design, Setting, and […]

Survival of community-dwelling older people: the effect of cognitive impairment and social engagement
Objectives: To examine the association and interaction between cognitive impairment and social support and mortality.; Design: Prospective cohort study.; Setting: Fifty-three family practices in the United Kingdom.; Participants: Community-dwelling people (aged > or =75) participating in the Medical Research Council Trial of the Assessment and Management of Older People in the Community (10,720 individual subjects […]

The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment
Background/objectives: Previous research investigating the impact of glucose ingestion and/or improvements in glucose regulation has found selective cognitive facilitation on episodic memory tasks in successful ageing and dementia. The present study aimed to extend this research to mild cognitive impairment (MCI).; Subjects/methods: In a repeated-measures design, 24 older adults with and 24 older adults without […]

Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil
Objectives: Change in cognitive function in response to a pharmacologic challenge can be observed with greater sensitivity by employing cognitive tests with optimal psychometric properties and a statistical approach that more accurately accounts for individual variability in performance. To demonstrate this approach we examined the cognitive effects of a single acute dose administration of an […]

Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging
Background and Purpose: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine the effect of such therapy on the neural substrates underlying memory processing in subjects with MCI by using functional MR imaging […]

Spaced retrieval significantly improves prospective memory performance of cognitively impaired older adults
Background: Although memory for future intentions (prospective memory, PM) is compromised in older adults with cognitive impairment, the effectiveness of specific training techniques to help these older adults with PM tasks remains unclear.; Objective: The present study examined the effectiveness of spaced retrieval (rehearsing at increasingly spaced intervals) as an intervention for improving PM in […]

Mobility training after hip fracture: a randomised controlled trial
Objective: to compare the effects of two different exercise programmes after hip fracture.; Design: assessor-blinded randomised controlled trial.; Setting: hospital rehabilitation units, with continued intervention at home.; Subjects: 160 people with surgical fixation for hip fracture transferred to inpatient rehabilitation.; Method: in addition to other rehabilitation strategies, the intervention group received a higher dose (60 […]

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
A double-blind, parallel-group, placebo-controlled trial was performed on 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Hericium erinaceus), an edible mushroom, for improving cognitive impairment, using a cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R). After 2 […]

Donepezil delays progression to AD in MCI subjects with depressive symptoms
Objective: To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship.; Methods: The study sample was composed of 756 participants with aMCI from the 3-year, double-blind, placebo-controlled Alzheimer’s Disease Cooperative Study drug trial […]

Early intervention for mild cognitive impairment: a randomised controlled trial
Background: Positive effects are reported for memory training for healthy older adults, and yet there is limited information about the benefit of cognitive intervention for older adults with increasing memory difficulties-mild cognitive impairment.; Objective: To investigate the usefulness of an early cognitive intervention for the memory difficulties experienced by people with amnestic mild cognitive impairment.; […]

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