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Articles by: Pietrzak, R. H.

Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil

Objectives: Change in cognitive function in response to a pharmacologic challenge can be observed with greater sensitivity by employing cognitive tests with optimal psychometric properties and a statistical approach that more accurately accounts for individual variability in performance. To demonstrate this approach we examined the cognitive effects of a single acute dose administration of an […]

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