This database contains 523 studies, archived under the term: "Alzheimer’s Disease"
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Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]
Concentration of donepezil to the cognitive response in Alzheimer disease
Yang, Yuan-Han,
Chen, Chun-Hung,
Chou, Mei-Chuan,
Li, Chien-Hsun,
Liu, Ching-Kuan,
Chen, Su-Hwei
Background: Donepezil has been approved, and higher dosages are recommended for the treatment of Alzheimer disease (AD). However, a few studies have reported different cognitive responses in patients with AD treated with donepezil without measuring the concentration.; Methods: We evaluated the relationships between the therapeutic responses and plasma concentrations of donepezil in various cognitive domains […]
Effect of rhythmic auditory cueing on gait in people with Alzheimer disease
Objective: To determine whether rhythmic music and metronome cues alter spatiotemporal gait measures and gait variability in people with Alzheimer disease (AD).; Design: A repeated-measures study requiring participants to walk under different cueing conditions.; Setting: University movement laboratory.; Participants: Of the people (N=46) who met study criteria (a diagnosis of probable AD and ability to […]
Walking stabilizes cognitive functioning in Alzheimer’s disease (AD) across one year
Winchester, J.,
Dick, M.B.,
Gillen, D.,
Reed, B.,
Miller, B.,
Tinklenberg, J.,
Mungas, D.,
Chui, H.,
Galasko, D.,
Hewett, L.,
Cotman, C.W.
AD is a public health epidemic, which seriously impacts cognition, mood and daily activities; however, one type of activity, exercise, has been shown to alter these states. Accordingly, we sought to investigate the relationship between exercise and mood, in early-stage AD patients (N=104) from California, over a 1-year period. Patients completed the Mini-Mental State Examination […]
The GERAS study: A prospective observational study of costs and resource use in community dwellers with Alzheimer’s disease in three European countries—Study design and baseline findings
Wimo, Anders,
Reed, Catherine C.,
Dodel, Richard,
Belger, Mark,
Jones, Roy W.,
Happich, Michael,
Argimon, Josep M.,
Bruno, Giuseppe,
Novick, Diego,
Vellas, Bruno,
Haro, Josep Maria
To address socioeconomic challenges associated with its increasing prevalence, data are needed on country-level resource use and costs associated with Alzheimer’s disease (AD). GERAS is an 18-month observational study being conducted in France, Germany, and the UK (with an 18-month extension in France and Germany), aimed at determining resource use and total costs associated with […]
Video-based coping skills to reduce health risk and improve psychological and physical well-being in Alzheimer’s disease family caregivers
Williams, Virginia P.,
Bishop-Fitzpatrick, Lauren,
Lane, James D.,
Gwyther, Lisa P.,
Ballard, Edna L.,
Vendittelli, Analise P.,
Hutchins, Tiffany C.,
Williams, Redford B.
Objective: To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer’s disease or related dementia (ADRD).; Methods: A controlled clinical trial was conducted with 116 ADRD caregivers who were assigned, alternately as they qualified for the study, to a […]
Response to cholinesterase inhibitors affects lifespan in Alzheimer’s disease
Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer’s disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical […]