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Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease


Cumbo, Eduardo, Ligori, Leonarda D.


Epilepsy & Behavior: E&B, Volume: 17, No.: 4, Pages.: 461-466

Year of Publication



The objective of the study described here was to evaluate the efficacy, tolerability, and cognitive effects of levetiracetam (LEV) in patients with seizures and Alzheimer’s disease (AD). This was a prospective, randomized, three-arm parallel-group, case-control study of 95 patients taking LEV (n=38), phenobarbital (PB) (n=28), and lamotrigine (LTG) (n=29). A 4-week dose adjustment was followed by a 12-month evaluation period. The three groups were compared to a control group (n=68) to evaluate cognitive effects of the antiepileptic drugs. We examined drug effects cross-sectionally at baseline, 6 months, and 12 months. There were no significant differences in efficacy among the three AEDs. LEV caused fewer adverse events than the other AEDs. PB produced persistent negative cognitive side effects. LEV was associated with improved cognitive performance, specifically attention level and oral fluency items. LTG had a better effect on mood. LEV had a benign neuropsychological side effect profile, making it a cognitively safe drug to use for controlling established seizures in elderly patients with Alzheimer’s disease.; Copyright (c) 2010 Elsevier Inc. All rights reserved.

Bibtex Citation

@article{Cumbo_2010, doi = {10.1016/j.yebeh.2010.01.015}, url = {}, year = 2010, month = {apr}, publisher = {Elsevier {BV}}, volume = {17}, number = {4}, pages = {461--466}, author = {Eduardo Cumbo and Leonarda D. Ligori}, title = {Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease}, journal = {Epilepsy {&} Behavior} }


adverse, adverse effects, aged, aged, 80 and over, alzheimer disease, analogs derivatives, analysis of variance, anticonvulsants, cognition disorders, complications, double-blind method, drug therapy, electroencephalography, epilepsy, etiology, events, female, humans, lamotrigine, levetiracetam, male, mental status schedule, methods, middle aged, neuropsychological tests, phenobarbital, piracetam, therapeutic use, time factors, treatment outcome, triazines

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes

Cognition, Depression and Anxiety, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions