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Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer’s disease


Babiloni, Claudio, Frisoni, Giovanni B., Del Percio, Claudio, Zanetti, Orazio, Bonomini, Cristina, Cassetta, Emanuele, Pasqualetti, Patrizio, Miniussi, Carlo, De Rosas, Mario, Valenzano, Anna, Cibelli, Giuseppe, Eusebi, Fabrizio, Rossini, Paolo M.


Clinical Neurophysiology: Official Journal Of The International Federation Of Clinical Neurophysiology, Volume: 120, No.: 4, Pages.: 709-718

Year of Publication



Objective: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer’s disease (AD). Here we evaluated the hypothesis that long-term ibuprofen treatment affects cortical sources of resting electroencephalographic (EEG) rhythms in mild AD patients.; Methods: Twenty-three AD patients (13 treated AD IBUPROFEN; 10 untreated AD PLACEBO) were enrolled. Resting EEG data were recorded before and 1 year after the ibuprofen/placebo treatment. EEG rhythms were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). LORETA was used for EEG source analysis.; Results: In the AD PLACEBO group, amplitude of delta sources was globally greater at follow-up than baseline. Instead, amplitude of delta sources remained stable or decreased in the majority of the AD IBUPROFEN patients. Clinical (CDR) but not global cognitive status (MMSE) reflected EEG results.; Conclusions: These results suggest that in mild AD patients, a long-term ibuprofen treatment slightly slows down the progressive increment of delta rhythms as a sign of contrast against the neurodegenerative processes.; Significance: They motivate future investigations with larger population and extended neuropsychological testing, to study the relationships among ibuprofen treatment, delta cortical sources, and higher order functions.;

Bibtex Citation

@article{Babiloni_2009, doi = {10.1016/j.clinph.2009.02.005}, url = {}, year = 2009, month = {apr}, publisher = {Elsevier {BV}}, volume = {120}, number = {4}, pages = {709--718}, author = {Claudio Babiloni and Giovanni B. Frisoni and Claudio Del Percio and Orazio Zanetti and Cristina Bonomini and Emanuele Cassetta and Patrizio Pasqualetti and Carlo Miniussi and Mario De Rosas and Anna Valenzano and Giuseppe Cibelli and Fabrizio Eusebi and Paolo M. Rossini}, title = {Ibuprofen treatment modifies cortical sources of {EEG} rhythms in mild Alzheimer's disease}, journal = {Clinical Neurophysiology} }


aged, alzheimer disease, analysis of variance, brain mapping, cerebral cortex, drug effects, drug therapy, eed, electroencephalography, female, humans, ibuprofen, longitudinal studies, magnetic resonance imaging, male, methods, neuropsychological tests, pathology, pharmacology, physiopathology, prevention & control, reference values, rhythms, set, spectrum analysis, therapeutic use

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Case Control Study

Type of Outcomes

Other, Physical Health

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions