Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

Authors

Schöll, Michael, Almkvist, Ove, Axelman, Karin, Stefanova, Elka, Wall, Anders, Westman, Eric, Långström, Bengt, Lannfelt, Lars, Graff, Caroline, Nordberg, Agneta

Journal

Neurobiology Of Aging, Volume: 32, No.: 8, Pages.: 1388-1399

Year of Publication

2011

Abstract

Six young related pre-symptomatic carriers of a His163Tyr mutation in the presenilin 1 gene who will develop early onset familial Alzheimer’s disease (eoFAD), and a control group of 23 non-carriers underwent (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). The mutation carriers were followed-up after 2 years. Multivariate analysis showed clear separation of carriers from non-carriers on both occasions, with the right thalamus being the region contributing most to group differentiation. Statistical parametric mapping (SPM) revealed in the carriers non-significantly lower thalamic cerebral glucose metabolism (CMRglc) at baseline and significantly decreased CMRglc in the right thalamus at follow-up. One mutation carrier was followed-up with FDG PET 10 years after baseline and showed reductions in cognition and CMRglc in the posterior cingulate and the frontal cortex. This subject was diagnosed with AD 1 year later and assessed with an additional FDG as well as an (11)C-PIB PET scan 12 years after baseline. Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels.; Copyright © 2009 Elsevier Inc. All rights reserved.

Bibtex Citation

@article{Sch_ll_2011, doi = {10.1016/j.neurobiolaging.2009.08.016}, url = {http://dx.doi.org/10.1016/j.neurobiolaging.2009.08.016}, year = 2011, month = {aug}, publisher = {Elsevier {BV}}, volume = {32}, number = {8}, pages = {1388--1399}, author = {Michael Schöll and Ove Almkvist and Karin Axelman and Elka Stefanova and Anders Wall and Eric Westman and Bengt L{aa}ngström and Lars Lannfelt and Caroline Graff and Agneta Nordberg}, title = {Glucose metabolism and {PIB} binding in carriers of a His163Tyr presenilin 1 mutation}, journal = {Neurobiology of Aging} }

Keywords

adult, age of onset, aged, aged, 80 and over, alzheimer disease, benzothiazoles, blood glucose, carbon radioisotopes, corpus striatum, diagnosis, diagnostic use, female, genetics, humans, male, metabolism, methods, middle aged, point mutation, presenilin1, radionuclide imaging

Countries of Study

Sweden

Types of Dementia

Alzheimer’s Disease

Types of Study

Cohort Study

Type of Outcomes

Other

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Neuroimaging (e.g. MRI, PET, CAT etc.)