Viscogliosi, Giovanni, Andreozzi, Paola, Chiriac, Iulia Maria, Cipriani, Elisa, Servello, Adriana, Ettorre, Evaristo, Marigliano, Vincenzo

Background: Metabolic syndrome reaches its highest prevalence in the elderly, and evidence suggests that metabolic syndrome could be an independent risk factor for cognitive impairment. The aims of this study were to detect whether patients with metabolic syndrome have lower cognition and to investigate whether there is a relationship with cognition and single metabolic syndrome […]

Cooper, Sally-Ann, Caslake, Muriel, Evans, Jonathan, Hassiotis, Angela, Jahoda, Andrew, McConnachie, Alex, Morrison, Jill, Ring, Howard, Starr, John, Stiles, Ciara, Sullivan, Frank

Background: Early-onset dementia is common in Down syndrome adults, who have trisomy 21. The amyloid precursor protein gene is on chromosome 21, and so is over-expressed in Down syndrome, leading to amyloid β (Aβ) over-production, a major upstream pathway leading to Alzheimer disease (AD). Statins (microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), have pleiotropic effects including […]

Schöll, Michael, Almkvist, Ove, Axelman, Karin, Stefanova, Elka, Wall, Anders, Westman, Eric, Långström, Bengt, Lannfelt, Lars, Graff, Caroline, Nordberg, Agneta

Six young related pre-symptomatic carriers of a His163Tyr mutation in the presenilin 1 gene who will develop early onset familial Alzheimer’s disease (eoFAD), and a control group of 23 non-carriers underwent (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). The mutation carriers were followed-up after 2 years. Multivariate analysis showed clear separation of carriers from non-carriers on […]

Brommelhoff, Jessica A., Gatz, Margaret, Johansson, Boo, McArdle, John J., Fratiglioni, Laura, Pedersen, Nancy L.

This study tested whether history of depression is associated with an increased likelihood of dementia, and whether a first depressive episode earlier in life is associated with increased dementia risk, or whether only depressive episodes close in time to dementia onset are related to dementia. Depression information came from national hospital discharge registries, medical history, […]