Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]

Moretti, Davide V., Frisoni, Giovanni B., Binetti, Giuliano, Zanetti, Orazio

Background: Alzheimer’s disease (AD) is the most common cause of dementia in older patients. Rivastigmine (RV, Exelon, Novartis), a reversible cholinesterase inhibitor, improves clinical manifestations of AD and may enhance ACh-modulated electroencephalogram (EEG) alpha frequency. This pilot study aimed to determine the effects of two formulations of RV [transdermal patch (RV-TDP) and oral capsules (TV-CP)] […]

Kang, Hee-Young, Bae, Yeong-Suk, Kim, Eun-Hee, Lee, Kap-Soon, Chae, Myeong-Jeong, Ju, Ree-Aie

Called dotage in Korea, dementia is primarily characterized by cognitive impairments. Secondary manifestations include mental- emotional problems, including depression. This study was designed to examine the effects of an integrated dementia intervention for Korean older adults. The intervention is composed of cognitive stimulation training, exercise, music, art, and horticultural therapy. Participants included 38 older adults […]