Volandes, Angelo E., Paasche-Orlow, Michael K., Barry, Michael J., Gillick, Muriel R., Minaker, Kenneth L., Chang, Yuchiao, Cook, E. Francis, Abbo, Elmer D., El-Jawahri, Areej, Mitchell, Susan L.

Objective: To evaluate the effect of a video decision support tool on the preferences for future medical care in older people if they develop advanced dementia, and the stability of those preferences after six weeks.; Design: Randomised controlled trial conducted between 1 September 2007 and 30 May 2008. Setting Four primary care clinics (two geriatric […]

Subramaniam, Ponnusamy, Woods, Bob, Whitaker, Chris

Objectives: To evaluate the effect of different pathways for developing a life story book (LSB) for people with dementia.; Method: Preliminary randomised control trial; 23 people with dementia in care homes (mean age 86) randomly assigned to receive either 12 individual life review sessions and co-creating a LSB or a personal LSB created by their […]

Schölzel-Dorenbos, Carla J M, Arons, Alexander M M, Wammes, Joost J G, Rikkert, MarcelGMOlde, Krabbe, Paul F M

Background: Index measures for health-related quality of life (HRQoL) quantify the desirability (utility) of a certain health state. The commonly used generic index measure, e.g. EuroQol: EQ-5D, may underestimate relevant areas of specific diseases, resulting in lower validity. Disease-specific index measures on the other hand combine disease-specificity and quantification of perceived quality on several health […]

Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]