This database contains 32 studies, archived under the term: "time"
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The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington’s disease
Barker, Roger A,
Mason, Sarah L.,
Harrower, Timothy P.,
Swain, Rachel A.,
Ho, Aileen K.,
Sahakian, Barbara J.,
Mathur, Raj,
Elneil, Sohier,
Thornton, Steven,
Hurrelbrink, Carrie,
Armstrong, Richard J.,
Tyers, Pam,
Smith, Emma,
Carpenter, Adrian,
Piccini, Paola,
Tai, Yen F.,
Brooks, David J.,
Pavese, Nicola,
Watts, Colin,
Pickard, John D.,
Rosser, Anne E.,
Dunnett, Stephen B.
Huntington’s disease (HD) is a fatal autosomal dominant neurodegenerative disease involving progressive motor, cognitive and behavioural decline, leading to death approximately 20 years after motor onset. The disease is characterised pathologically by an early and progressive striatal neuronal cell loss and atrophy, which has provided the rationale for first clinical trials of neural repair using […]
Healing gardens and cognitive behavioral units in the management of Alzheimer’s disease patients: the Nancy experience
Rivasseau Jonveaux, T.,
Batt, M.,
Fescharek, R.,
Benetos, A.,
Trognon, A.,
Bah Chuzeville, S.,
Pop, A.,
Jacob, C.,
Yzoard, M.,
Demarche, L.,
Soulon, L.,
Malerba, G.,
Bouvel, B.
The French Alzheimer Plan 2008-2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer’s disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to provide support and educational therapy […]
Being overweight in midlife is associated with lower cognitive ability and steeper cognitive decline in late life
Dahl, Anna,
Hassing, Linda B.,
Fransson, Eleonor,
Berg, Stig,
Gatz, Margaret,
Reynolds, Chandra A.,
Pedersen, Nancy L.
Background: Although an increasing body of evidence links being overweight in midlife with an increased risk for dementia in late life, no studies have examined the association between being overweight in midlife and cognitive ability in late life. Our aim was to examine the association between being overweight in midlife as measured by body mass […]
The Tailored Activity Program to reduce behavioral symptoms in individuals with dementia: feasibility, acceptability, and replication potential
Gitlin, Laura N,
Winter, Laraine,
Vause Earland, Tracey,
Adel Herge, E.,
Chernett, Nancy L.,
Piersol, Catherine V.,
Burke, Janice P.
Purpose: The Tailored Activity Program (TAP) is a home-based occupational therapy intervention shown to reduce behavioral symptoms and caregiver burden in a randomized trial. This article describes TAP, its assessments, acceptability, and replication potential.; Design and Methods: TAP involves 8 sessions for a period of 4 months. Interventionists identify preserved capabilities, previous roles, habits, and […]
Family care as collaboration: effectiveness of a multicomponent support program for elderly couples with dementia. Randomized controlled intervention study
Eloniemi-Sulkava, Ulla,
Saarenheimo, Marja,
Laakkonen, Marja-Liisa,
Pietilä, Minna,
Savikko, Niina,
Kautiainen, Hannu,
Tilvis, Reijo S.,
Pitkälä, Kaisu H.
Objectives: To determine whether community care of people with dementia can be prolonged with a 2-year multicomponent intervention program and to analyze effects of the intervention on total usage and expenses of social and healthcare services.; Design: Randomized controlled trial.; Setting: Community-dwelling couples with one spouse caring for the other spouse with dementia.; Participants: Couples […]
Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial
Barnes, Deborah E.,
Yaffe, Kristine,
Belfor, Nataliya,
Jagust, William J.,
DeCarli, Charles,
Reed, Bruce R.,
Kramer, Joel H.
We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment. The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar […]
Long-term follow-up of patients immunized with AN1792: reduced functional decline in antibody responders
Vellas, Bruno,
Black, R.,
Thal, Leon J.,
Fox, Nick C.,
Daniels, M.,
McLennan, G.,
Tompkins, C.,
Leibman, C.,
Pomfret, M.,
Grundman, Michael
Background: Immunization of patients with Alzheimer’s disease (AD) with synthetic amyloid-beta peptide (Abeta(42)) (AN1792) was previously studied in a randomized, double-blind, placebo-controlled phase 2a clinical trial, Study AN1792(QS-21)-201. Treatment was discontinued following reports of encephalitis. One year follow-up revealed that AN1792 antibody responders showed improvements in cognitive measures as assessed by the neuropsychological test battery […]
Vitamins B(12), B(6), and folic acid for cognition in older men
Ford, A. H.,
Flicker, L.,
Alfonso, H.,
Thomas, J.,
Clarnette, R.,
Martins, R.,
Almeida, O. P.
Objective: To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function.; Methods: The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was […]