This database contains 40 studies, archived under the term: "AD patients"
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Quality of life and Alzheimer’s disease: The influence of participation in a rehabilitation center
Machado, Fernanda,
Nunes, Paula V.,
Viola, Luciane F.,
Santos, Franklin S.,
Forlenza, Orestes V.,
Yassuda, Mônica S.
Quality of life is seldom explored in evaluations of therapeutic interventions in Alzheimer’s disease. Objective: To verify whether participation in a cognitive and functional rehabilitation program improves quality of life (QOL) among Alzheimer’s disease (AD) patients. Methods: 19 AD patients participated in this study, 12 of whom attended 24 multi-professional intervention sessions—the experimental group—whereas the […]
Estimation and validation of a multiattribute model of Alzheimer disease progression
Stallard, Eric,
Kinosian, Bruce,
Zbrozek, Arthur S.,
Yashin, Anatoliy I.,
Glick, Henry A.,
Stern, Yaakov
Objectives: To estimate and validate a multiattribute model of the clinical course of Alzheimer disease (AD) from mild AD to death in a high-quality prospective cohort study, and to estimate the impact of hypothetical modifications to AD progression rates on costs associated with Medicare and Medicaid services. Data and Methods: The authors estimated sex-specific longitudinal […]
Brain stimulation in Alzheimer disease
Cotelli, Maria,
Manentil, Rosa,
Rosini, Sandra,
Brambilla, Michela,
Zanetti, Orazio,
Miniussi, Carlo
Recent studies have reported enhanced performance on specific cognitive tasks in patients with several types of neurological disease, after receiving non invasive brain stimulation (BS), i.e., repetitive Transcranial Magnetic Stimulation (rTMS) or transcranial Direct Current Stimulation (tDCS) to specific cortical areas. In addition, persistent beneficial effects of off-line rTMS on sentence comprehension in Alzheimer disease […]
Memantine in moderately-severe-to-severe Alzheimer’s disease: A postmarketing surveillance study
Clerici, Francesca,
Vanacore, Nicola,
Elia, Antonietta,
Spila-Alegiani, Stefania,
Pomati, Simone,
Da Cas, Roberto,
Raschetti, Roberto,
Mariani, Claudio
Background: Postmarketing surveillance studies (PMS) are an important tool for evaluating a drug’s effectiveness and safety in clinical practice. To our knowledge, no PMS on memantine monotherapy for moderately-severe-to-severe Alzheimer’s disease (AD) according to National Institute of Neurological and Communicative Disorders and Stroke—Alzheimer’s Disease and Related Disorders Association criteria has been conducted to date. Objective: […]
Achetylcholinesterase (AChE) inhibition and serum lipokines in Alzheimer’s disease: friend or foe?
Kovacs, Janos,
Pákáski, Magdolna,
Juhasz, Anna,
Feher, Agnes,
Drótos, Gergely,
Fazekas, Csilla Orsike,
Horvath, Tamas Laszlo,
Janka, Zoltan,
Kálmán, János
Throughout the natural progression of Alzheimer’s disease (AD), the body mass index (BMI) decreases. This is believed to be brought on by the disturbance in the central lipid metabolism, but the exact mechanism is yet unknown. Adipokines (adiponectin, leptin), hormones produced by the adipose tissue, change glucose and lipid metabolism, and have an anorectic effect […]
Effects of lexical-semantic treatment on memory in early Alzheimer disease: an observer-blinded randomized controlled trial
Jelcic, Nela,
Cagnin, Annachiara,
Meneghello, Francesca,
Turolla, Andrea,
Ermani, Mario,
Dam, Mauro
Background: Episodic memory and semantic abilities deteriorate early in Alzheimer disease (AD). Since the cognitive system includes interconnected and reciprocally influenced neuronal networks, the authors hypothesized that stimulation of lexical-semantic abilities may benefit semantically structured episodic memory.; Objective: To investigate the effects of lexical-semantic stimulation (LSS) on verbal communication and episodic memory in early AD.; […]
The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study design
Devanand, D. P.,
Mintzer, Jacobo,
Schultz, Susan,
Sultzer, David,
de la Pena, Danilo,
Gupta, Sanjay,
Colon, Sylvia,
Schimming, Corbett,
Pelton, Gregory H.,
Andrews, Howard,
Levin, Bruce
Objectives: : Research studies on the effects of discontinuing antipsychotic medications in patients with dementia have not identified specific target symptoms or response to antipsychotics prior to discontinuation. The Antipsychotic Discontinuation in Alzheimer Disease (ADAD) trial addresses these issues in a randomized, double-blind, placebo-controlled, multicenter risperidone treatment and discontinuation trial. In Phase A, AD patients […]