This database contains 109 studies, archived under the term: "At risk population"
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Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress
Richard, Edo,
Van den Heuvel, Esther,
Moll van Charante, Eric P.,
Achthoven, Lenny,
Vermeulen, Marinus,
Bindels, Patrick J.,
van Gool, Willem A.
Background and Purpose: Cardiovascular risk factors are associated with an increased risk of dementia. Treatment of hypertension and hypercholesterolemia is associated with a decrease in incident dementia. Whether interventions aimed at cardiovascular risk factors in late life also reduce dementia risk is unknown. Here, we report the outline of a pragmatic study that will attempt […]
The effects of glucose ingestion and glucose regulation on memory performance in older adults with mild cognitive impairment
Riby, L. M.,
Marriott, A.,
Bullock, R.,
Hancock, J.,
Smallwood, J.,
McLaughlin, J.
Background/objectives: Previous research investigating the impact of glucose ingestion and/or improvements in glucose regulation has found selective cognitive facilitation on episodic memory tasks in successful ageing and dementia. The present study aimed to extend this research to mild cognitive impairment (MCI).; Subjects/methods: In a repeated-measures design, 24 older adults with and 24 older adults without […]
Donepezil delays progression to AD in MCI subjects with depressive symptoms
Lu, P. H.,
Edland, S. D.,
Teng, E.,
Tingus, K.,
Petersen, R. C.,
Cummings, J. L.
Objective: To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship.; Methods: The study sample was composed of 756 participants with aMCI from the 3-year, double-blind, placebo-controlled Alzheimer’s Disease Cooperative Study drug trial […]
Vitamins B(12), B(6), and folic acid for cognition in older men
Ford, A. H.,
Flicker, L.,
Alfonso, H.,
Thomas, J.,
Clarnette, R.,
Martins, R.,
Almeida, O. P.
Objective: To investigate whether supplementing older men with vitamins B(12), B(6), and folic acid improves cognitive function.; Methods: The investigators recruited 299 community-representative hypertensive men 75 years and older to a randomized, double-blind controlled clinical trial of folic acid, vitamin B(6), and B(12) supplementation vs placebo over 2 years. The primary outcome of interest was […]
The UP-TECH project, an intervention to support caregivers of Alzheimer’s disease patients in Italy: study protocol for a randomized controlled trial
Chiatti, Carlos,
Masera, Filippo,
Rimland, Joseph M.,
Cherubini, Antonio,
Scarpino, Osvaldo,
Spazzafumo, Liana,
Lattanzio, Fabrizia
Background: The epidemic of Alzheimer’s disease (AD) represents a significant challenge for the health care and social service systems of many developed countries. AD affects both patients and family caregivers, on whom the main burden of care falls, putting them at higher risk of stress, anxiety, mortality and lower quality of life. Evidence remains controversial […]
Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): A double-blind brain potential study
Yang, Jin-Chen,
Niu, Yu-Qiong,
Simon, Christa,
Seritan, Andreea L,
Chen, Lawrence,
Schneider, Andrea,
Moghaddam, Shayan T,
Hagerman, Paul J,
Hagerman, Randi J,
Olichney, John M
Older FMR1 premutation carriers may develop fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder manifesting cognitive deficits that often subsequently progress to dementia. To date, there is no specific treatment available for FXTAS. Studies have demonstrated the premutation-associated overactivation of glutamatergic receptors in neurons. Memantine, a NMDA receptor antagonist approved for treatment of Alzheimer’s disease, […]
Adaptive cognitive testing in cerebrovascular disease and vascular dementia
Wouters, Hans,
de Koning, Inge,
Zwinderman, Aeilko H.,
van Gool, Willem A.,
Schmand, Ben,
Buiter, Maarten,
Lindeboom, Robert
Background/aims: To examine whether brevity can be combined with precision in measuring global cognitive ability in patients with cerebrovascular disease (CVD) or vascular dementia (VaD). Longer tests (e.g. the CAMCOG) are precise but inefficient, whereas brief tests (e.g. the MMSE) are efficient but imprecise.; Methods: A simulated computerized adaptive testing (CAT) algorithm using existing CAMCOG […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]