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Antihypertensive agents and risk of Parkinson’s disease, essential tremor and dementia: a population-based prospective study (NEDICES)


Louis, Elan D., Benito-León, Julián, Bermejo-Pareja, Félix


Neuroepidemiology, Volume: 33, No.: 3, Pages.: 286-292

Year of Publication



Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET).; Objective: To examine the association between antihypertensive use (defined broadly and by individual subclasses) and ET, PD and dementia. For each disorder, we used cross-sectional data (association with prevalent disease) and prospective data (association with incident disease).; Methods: Prospective population-based study in Spain enrolling 5,278 participants at baseline.; Results: Use of antihypertensive medications (aside from beta-blockers) was similar in prevalent ET cases and controls. Baseline use of antihypertensive agents was not associated with reduced risk of incident ET. Antihypertensive medication use was not associated with prevalent or incident PD. Calcium channel blocker use was marginally reduced in prevalent dementia cases (OR(adjusted) = 0.63, p = 0.06) but was not associated with reduced risk of incident dementia (RR(adjusted) = 1.02, p = 0.95).; Conclusions: We did not find evidence of a protective effect of antihypertensive medications in these three neurodegenerative disorders.; Copyright 2009 S. Karger AG, Basel.

Bibtex Citation

@article{Louis_2009, doi = {10.1159/000235641}, url = {}, year = 2009, publisher = {S. Karger {AG}}, volume = {33}, number = {3}, pages = {286--292}, author = {Elan D. Louis and Juli{&}aacute$mathsemicolon$n Benito-Le{&}oacute$mathsemicolon$n and F{&}eacute$mathsemicolon$lix Bermejo-Pareja}, title = {Antihypertensive Agents and Risk of Parkinson{&}rsquo$mathsemicolon$s Disease, Essential Tremor and Dementia: A Population-Based Prospective Study ({NEDICES})}, journal = {Neuroepidemiology} }


adverse effects, aged, aged, 80 and over, agents, antihypertensive, antihypertensive agents, dementia, epidemiology, essential tremor, female, humans, male, nervous system diseases, parkinson disease, population surveillance, prevention & control, prospective studies, risk factors, spain, therapeutic use

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Cohort Study

Type of Outcomes

Risk reduction (of dementia and co-morbidities)

Type of Interventions

Pharmaceutical Interventions, Risk Factor Modification

Risk Factor Modifications

At risk population

Pharmaceutical Interventions