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Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up
Zelinski, Elizabeth M.,
Spina, Laila M.,
Yaffe, Kristine,
Ruff, Ronald,
Kennison, Robert F.,
Mahncke, Henry W.,
Smith, Glenn E.
Objectives: To investigate maintenance of training effects of a novel brain plasticity-based computerized cognitive training program in older adults after a 3-month no-contact period.; Design: Multisite, randomized, controlled, double-blind trial with two treatment groups.; Setting: Communities in northern and southern California and Minnesota.; Participants: Four hundred eighty-seven community-dwelling adults aged 65 and older without diagnosis […]
Evaluations of dementia by EEG frequency analysis and psychological examination
In order to evaluate the stage of dementia, we focused attention on EEG rhythms and Hasegawa-dementia-rating scale (HDS-R). Frontal EEGs were recorded from dementia patients and normal controls during music and photo-image stimulations, and frequency analysis was performed. In the controls, profiles of rhythm pattern during music stimulation seemed to be markedly different from those […]
Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]
Concentration of donepezil to the cognitive response in Alzheimer disease
Yang, Yuan-Han,
Chen, Chun-Hung,
Chou, Mei-Chuan,
Li, Chien-Hsun,
Liu, Ching-Kuan,
Chen, Su-Hwei
Background: Donepezil has been approved, and higher dosages are recommended for the treatment of Alzheimer disease (AD). However, a few studies have reported different cognitive responses in patients with AD treated with donepezil without measuring the concentration.; Methods: We evaluated the relationships between the therapeutic responses and plasma concentrations of donepezil in various cognitive domains […]
Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): A double-blind brain potential study
Yang, Jin-Chen,
Niu, Yu-Qiong,
Simon, Christa,
Seritan, Andreea L,
Chen, Lawrence,
Schneider, Andrea,
Moghaddam, Shayan T,
Hagerman, Paul J,
Hagerman, Randi J,
Olichney, John M
Older FMR1 premutation carriers may develop fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder manifesting cognitive deficits that often subsequently progress to dementia. To date, there is no specific treatment available for FXTAS. Studies have demonstrated the premutation-associated overactivation of glutamatergic receptors in neurons. Memantine, a NMDA receptor antagonist approved for treatment of Alzheimer’s disease, […]
Effects of cognitive stimulation therapy Japanese version (CST-J) for people with dementia: a single-blind, controlled clinical trial
Yamanaka, Katsuo,
Kawano, Yoshiyuki,
Noguchi, Dai,
Nakaaki, Shutaro,
Watanabe, Norio,
Amano, Takashi,
Spector, Aimee
Objectives: Cognitive stimulation therapy (CST) has shown to have significant benefits in improving the cognitive function and quality of life (QOL) in people with mild-to-moderate dementia in a UK randomized controlled trial (RCT). We developed and examined the Japanese version of group CST (CST-J) in a single-blind, controlled clinical trial.; Method: CST-J consisting of 14 […]
A simple cognitive test which detects early decline in cognitive function
Aim: The aim of this study was to examine our new cognitive test which detects early decline in cognitive function.; Methods: Our newly developed Simple Cognitive test (SC-test) takes 3 minutes, during which participants choose the figures in which both the shape and color are different from the figure on the left end of each […]