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What predicts cognitive decline in de novo Parkinson’s disease?
Arnaldi, Dario,
Campus, Claudio,
Ferrara, Michela,
Famà, Francesco,
Picco, Agnese,
De Carli, Fabrizio,
Accardo, Jennifer,
Brugnolo, Andrea,
Sambuceti, Gianmario,
Morbelli, Silvia,
Nobili, Flavio
Subtle cognitive impairment can be detected in early Parkinson’s disease (PD). In a consecutive series of de novo, drug-naive PD patients, we applied stepwise regression analysis to assess...
The diagnostic efficiency of biomarkers in sporadic Creutzfeldt-Jakob disease compared to Alzheimer’s disease
Bahl, Justyna Maria Czarna,
Heegaard, Niels H.H.,
Falkenhorst, Gerhard,
Laursen, Henning,
Høgenhaven, Hans,
Mølbak, Kåre,
Jespersgaard, Cathrine,
Hougs, Lotte,
Waldemar, Gunhild,
Johannsen, Peter,
Christiansen, Michael
...We conclude that the combination of more than one CSF marker for neurodegeneration can improve the diagnostic test accuracy for sCJD against neurological controls including patients with other dementias.;...
Group therapy for patients with mild cognitive impairment and their significant others: Results of a waiting-list controlled trial
Banningh, Liesbeth W. A. Joosten-Weyn,
Prins, Judith B.,
Vernooij-Dassen, Myrra J. F. J.,
Wijnen, Hugo H.,
Rikkert, Marcel G. M. Olde,
Kessels, Roy P. C.
...two of three secondary outcome measures had higher baseline levels of helplessness and fewer self-reported memory complaints in daily life than patients who did not improve. Conclusion: The intervention helped...
Trazodone improves sleep parameters in Alzheimer disease patients: A randomized, double-blind, and placebo-controlled study
Camargos, Einstein F.,
Louzada, Luciana L.,
Quintas, Juliana L.,
Naves, Janeth O.S.,
Louzada, Fernando M.,
Nóbrega, Otávio T.
Objectives: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy...
Memantine effects measured with the Relevant Outcome Scale for Alzheimer’s disease in an open-label, single-arm, multicenter clinical study
Holthoff, Vjera,
Ferris, Steven,
Gauthier, Serge,
Ihl, Ralf,
Robert, Philippe,
Winblad, Bengt,
Sternberg, Kati,
Tennigkeit, Frank
...ROSA and four standard instruments — the Alzheimer’s disease Assessment Scale-cognitive (ADAS-cog), Severe Impairment Battery (SIB), Disability Assessment for Dementia (DAD), and the Neuropsychiatric Inventory (NPI) — were used in...
Mediterranean diet improves cognition: The PREDIMED-NAVARRA randomised trial
Martínez-Lapiscina, Elena H,
Clavero, Pedro,
Toledo, Estefania,
Estruch, Ramon,
Salas-Salvadó, Jordi,
San Julián, Beatriz,
Sanchez-Tainta, Ana,
Ros, Emilio,
Valls-Pedret, Cinta,
Martinez-Gonzalez, Miguel Á
...We used general linear models to control for potential confounding. Results: After adjustment for sex, age, education, Apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass...
Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer’s disease: the omega-3 Alzheimer’s disease study
Faxén Irving, Gerd,
Freund-Levi, Yvonne,
Eriksdotter-Jönhagen, Maria,
Basun, Hans,
Brismar, Kerstin,
Hjorth, Erik,
Palmblad, Jan,
Vessby, Bengt,
Vedin, Inger,
Wahlund, Lars-Olof,
Cederholm, Tommy
Objectives: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer’s disease (AD) in relation to...
Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study
Jackson, Graham S.,
Burk-Rafel, Jesse,
Edgeworth, Julie Ann,
Sicilia, Anita,
Abdilahi, Sabah,
Korteweg, Justine,
Mackey, Jonathan,
Thomas, Claire,
Wang, Guosu,
Schott, Jonathan M.,
Mummery, Catherine,
Chinnery, Patrick F.,
Mead, Simon,
Collinge, John
Importance: Our study indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity and specificity to justify a large study comparing vCJD prevalence in the United...