Likitjaroen, Y., Meindl, T., Friese, U., Wagner, M., Buerger, K., Hampel, H., Teipel, S. J.

Diffusion tensor imaging (DTI) demonstrates decline of fractional anisotropy (FA) as a marker of fiber tract integrity in Alzheimer’s disease (AD). We aimed to assess the longitudinal course of white matter microstructural changes in AD and healthy elderly control (HC) subjects and to evaluate the effects of treatment with the cholinesterase inhibitor galantamine on white […]

Carmichael, Owen, Schwarz, Christopher, Drucker, David, Fletcher, Evan, Harvey, Danielle, Beckett, Laurel, Jack, Clifford R., Jr., Weiner, Michael, DeCarli, Charles

Objective: To evaluate relationships between magnetic resonance imaging (MRI)-based measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, and 1-year cognitive decline using a large convenience sample in a clinical trial design with a relatively mild profile of cardiovascular risk factors.; Design: Convenience sample in a clinical trial design.; Subjects: A total of […]

Teipel, Stefan J., Reuter, Sigrid, Stieltjes, Bram, Acosta-Cabronero, Julio, Ernemann, Ulrike, Fellgiebel, Andreas, Filippi, Massimo, Frisoni, Giovanni, Hentschel, Frank, Jessen, Frank, Klöppel, Stefan, Meindl, Thomas, Pouwels, Petra J.W., Hauenstein, Karl-Heinz, Hampel, Harald

Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans […]

Richard, E., Gouw, A. A., Scheltens, P., van Gool, W. A.

Background and Purpose: White matter lesions (WMLs) and cerebral infarcts are common findings in Alzheimer disease and may contribute to dementia severity. WMLs and lacunar infarcts may provide a potential target for intervention strategies. This study assessed whether multicomponent vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs and prevents […]

Algin, O, Hakyemez, B, Parlak, M

The differentiation of idiopathic normal-pressure hydrocephalus (INPH) from other types of dementia is a clinical challenge. The aim of this prospective study was to evaluate the role of proton MR spectroscopy (MRS) and white matter hyperintensities (WMH) in the diagnosis of INPH, predicting response to therapy and differentiating INPH from other dementias. The study included […]