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Proton MR spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias


Algin, O, Hakyemez, B, Parlak, M


The British Journal Of Radiology, Volume: 83, No.: 993, Pages.: 747-752

Year of Publication



The differentiation of idiopathic normal-pressure hydrocephalus (INPH) from other types of dementia is a clinical challenge. The aim of this prospective study was to evaluate the role of proton MR spectroscopy (MRS) and white matter hyperintensities (WMH) in the diagnosis of INPH, predicting response to therapy and differentiating INPH from other dementias. The study included 18 patients with INPH (Group 1), 11 patients with other types of dementia (Group 2) and 20 control patients (Group 3). The value of WMH scores and MRS findings in diagnosis, evaluation of response to therapy and in the differentiation of INPH from other dementias was statistically evaluated. The level of statistical significance was set at p<0.05 (Kruskal-Wallis and Mann-Whitney U-test). In both Groups 1 and 2, N-acetylaspartate (NAA)/choline-NAA/creatine ratios were significantly less than in the control group (p<0.05). The WMH and MRS findings of Groups 1 and 2 demonstrated no statistically significant correlation (p>0.05). No correlation was found between the outcome of shunt operations and WMH and MRS findings (p>0.05). In conclusion, neither WMH nor MRS were useful in differentiating INPH from other types of dementia. WMH and MRS showed no additional benefit in identifying INPH patients who will better respond to shunt therapy.;

Bibtex Citation

@article{Algin_2010, doi = {10.1259/bjr/43131041}, url = {}, year = 2010, month = {sep}, publisher = {British Institute of Radiology}, volume = {83}, number = {993}, pages = {747--752}, author = {O Algin and B Hakyemez and M Parlak}, title = {Proton {MR} spectroscopy and white matter hyperintensities in idiopathic normal pressure hydrocephalus and other dementias}, journal = {The British Journal of Radiology} }


adult, aged, analogs derivatives, aspartic acid, choline, creatine, dementia vascular, diagnosis, diagnosis, differential, female, humans, hydrocephalus, hydrocephalus, normal pressure, idiopathic, magnetic resonance spectroscopy, male, metabolism, methods, middle aged, nerve fibers myelinated, normalpressure, pathology, prognosis, prospective studies, reproducibility of results, therapy

Countries of Study


Types of Study

Non randomised controlled trial

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Neuroimaging (e.g. MRI, PET, CAT etc.)