This database contains 542 studies, archived under the term: "middle aged"
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Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan
This study investigated whether an association exists between irritable bowel syndrome (IBS) and the risk of Parkinson’s disease. This is a retrospective cohort study using the dataset of the Taiwan National Health Insurance Program from 2000 to 2010. We identified 23,875 patients (aged 20 years or older) with newly diagnosed IBS as the IBS group […]
Language-enriched exercise plus socialization for older adults with dementia: translation to rural communities
Felten, Kristen,
Duschene, Kathie,
MacFarlane, Dana,
Price, Susan,
Zimmerman, Suanne,
Hafez, Stephanie,
La Rue, Asenath
Interventions that stimulate and engage individuals with dementia physically, cognitively, and socially offer promise for improving health and well-being and for potentially slowing functional losses with disease progression. We describe a volunteer-based intervention that combines physical exercise, cognitive-linguistic stimulation, and social outings for older persons living with dementia in rural communities. One-year follow-up data, although […]
A multicenter, open-label, 24-week follow-up study for efficacy on cognitive function of donepezil in Binswanger-type subcortical vascular dementia
Jay Cheol Kwon,,
Eung Gyu Kim,,
Jae Woo Kim,,
Oh Dae Kwon,,
Bong Goo Yoo,,
Hyon Ah Yi,,
Nack Cheon Choi,,
Seon Young Ahn,,
Byung Hwa Lee,,
Myong Jin Kang,,
Dae Seob Choi,
Objectives: To evaluate the efficacy and tolerability of donepezil in patients with Binswanger type subcortical vascular dementia.; Methods: Patients (n = 34, mean age = 71.8 + 7.12) with Binswanger type subcortical vascular dementia from 8 multicenter, according to clinical and neuroradiological working criteria, were selected to receive donepezil 5 mg/day (n = 2) or […]
Telephone-delivered psychoeducational intervention for Hong Kong Chinese dementia caregivers: a single-blinded randomized controlled trial
Kwok, Timothy,
Wong, Bel,
Ip, Isaac,
Chui, Kenny,
Young, Daniel,
Ho, Florence
Purpose: Many family caregivers of persons with dementia (PWD) are unable to participate in community center-based caregiver support services because of logistical constraints. This study evaluated the effectiveness of a telephone-delivered psychoeducational intervention for family caregivers of PWD in alleviating caregiver burden and enhancing caregiving self-efficacy.; Subjects and Methods: In a single-blinded randomized controlled trial, […]
Effectiveness of online cognitive behavioral therapy on family caregivers of people with dementia
Kwok, Timothy,
Au, Alma,
Wong, Bel,
Ip, Isaac,
Mak, Vivian,
Ho, Florence
Purpose: Family caregivers of persons with dementia (PWD) may receive caregiver training because of logistical constraints and privacy concerns. This study evaluated the effectiveness of an online intervention for family caregivers of PWD in improving their self-efficacy in managing behavioral and psychological symptoms of dementia (BPSD), and their emotion well-being.; Subjects and Methods: A total […]
The impact of TCARE® on service recommendation, use, and caregiver well-being
Purpose Of the Study: Findings are reported from a study that examined the effects of the Tailored Caregiver Assessment and Referral (TCARE®) protocol, a care management process designed to help family caregivers, on care planning and caregiver outcomes.; Design and Methods: A longitudinal, randomized controlled trial was conducted with 97 caregivers enrolled in a demonstration […]
A randomized trial of a CAM therapy for stress reduction in American Indian and Alaskan Native family caregivers
Korn, L.,
Logsdon, R. G.,
Polissar, N. L.,
Gomez-Beloz, A.,
Waters, T.,
Ryser, R.
Purpose: Although it is widely recognized that caregivers of individuals with dementia experience elevated stress that places them at increased risk for health problems, little is known about how caregiving stress may be alleviated among underserved ethnic minority populations. The purpose of this study was to compare a complementary and alternative medicine therapy, polarity therapy […]
Cost effectiveness of a manual based coping strategy programme in promoting the mental health of family carers of people with dementia (the START (STrAtegies for RelaTives) study): a pragmatic randomised controlled trial
Knapp, M.,
King, D.,
Romeo, R.,
Schehl, B.,
Barber, J.,
Griffin, M.,
Rapaport, P.,
Livingston, D.,
Mummery, C.,
Walker, Z.,
Hoe, J.,
Sampson, E. L.,
Cooper, C.,
Livingston, G.
Objective: To assess whether the START (STrAtegies for RelatTives) intervention added to treatment as usual is cost effective compared with usual treatment alone.; Design: Cost effectiveness analysis nested within a pragmatic randomised controlled trial.; Setting: Three mental health and one neurological outpatient dementia service in London and Essex, UK.; Participants: Family carers of people with […]
Phase II crossover trial of varenicline in mild-to-moderate Alzheimer’s disease
Kim, Seong Yoon,
Choi, Seong Hye,
Rollema, Hans,
Schwam, Elias M.,
McRae, Tom,
Dubrava, Sarah,
Jacobsen, Janice
Background: Evidence supports a role of α4β2 receptors in Alzheimer’s disease (AD).; Methods: This Korean, multicenter, double-blind, two-period (6 weeks each), crossover study randomized participants to the order in which they received varenicline (1 mg twice daily) and placebo. Assessments included AD Assessment Scale-Cognitive Subscale (ADAS-Cog) 75, Neuropsychiatric Inventory (NPI), adverse events (AEs) and Columbia-Suicide […]