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Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan


Lai, Shih-Wei, Liao, Kuan-Fu, Lin, Cheng-Li, Sung, Fung-Chang


European Journal Of Epidemiology, Volume: 29, No.: 1, Pages.: 57-62

Year of Publication



This study investigated whether an association exists between irritable bowel syndrome (IBS) and the risk of Parkinson’s disease. This is a retrospective cohort study using the dataset of the Taiwan National Health Insurance Program from 2000 to 2010. We identified 23,875 patients (aged 20 years or older) with newly diagnosed IBS as the IBS group and 95,500 subjects without IBS as the non-IBS group for comparison. The main outcome was incident Parkinson’s disease compared between both groups by the end of 2010. We measured the hazard ratio (HR) to evaluate the association between IBS and Parkinson’s disease. The overall incidence of Parkinson’s disease in the IBS group was 1.76-fold higher than that in the non-IBS group (16.4 vs. 9.33 per 10,000 person-years). The multivariable Cox proportional hazards regression analysis revealed that the adjusted HR of Parkinson’s disease associated with IBS was 1.48 (95% CI 1.27, 1.72), compared with the non-IBS group. Age, women, hypertension, dementia, cerebrovascular disease and depression were also significantly associated with Parkinson’s disease. Patients with irritable bowel syndrome are at an increased risk of developing Parkinson’s disease. Further studies are required to explore the pathophysiological connection between these disorders.;

Bibtex Citation

@article{Lai_2014, doi = {10.1007/s10654-014-9878-3}, url = {}, year = 2014, month = {jan}, publisher = {Springer Science $mathplus$ Business Media}, volume = {29}, number = {1}, pages = {57--62}, author = {Shih-Wei Lai and Kuan-Fu Liao and Cheng-Li Lin and Fung-Chang Sung}, title = {Irritable bowel syndrome correlates with increased risk of Parkinson's disease in Taiwan}, journal = {Eur J Epidemiol} }


adult, aged, aged, 80 and over, complications, diagnosis, epidemiology, female, humans, incidence, irritable bowel syndrome, male, middle aged, multivariate analysis, parkinson disease, proportional hazards models, retrospective studies, risk factors, taiwan, young adult

Countries of Study


Types of Dementia

Parkinson’s Dementia

Types of Study

Cohort Study

Type of Outcomes

Prevention and/or management of co-morbidities

Type of Interventions

Risk Factor Modification

Risk Factor Modifications

At risk population