This database contains 542 studies, archived under the term: "middle aged"
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Efficacy of acatinol memantine in mild cognitive disorder
An open 6 month clinical trial of efficacy of acatinol has been carried out in patients with mild cognitive disorder (MCD). Forty patients received acatinol and 20 patients of comparison group were treated with piracetam. Mean age of patients was 67,7+/-7,2 years. Patient’s state was assessed with a battery of scales, questionnaires and neuropsychological tests. […]
The effect of videophone communication (with skype and webcam)for elderly patients with dementia and their caregivers
Hori, Miyako,
Kubota, Masakazu,
Ando, Koichi,
Kihara, Takeshi,
Takahashi, Ryosuke,
Kinoshita, Ayae
We conducted an intervention study to clarify how effectively videophone (Skype) was used in the communication for elderly patients with dementia cared at home and their caregivers. For a period of 12 weeks, a patient-caregiver pair(n = 6) communicated with a nurse via computer for 30 minutes once a week. The patient and the caregiver […]
Galantamine (reminyl) in the treatment of severe Alzheimer’s disease
Twenty-five patients with Alzheimer’s disease (AD) in moderate-severe and severe stages received galantamine in dosage 8 mg daily during the 1st month with the following increasing to 16 mg daily. Six patients received 24 mg per day from the 3rd month. The total duration of therapy was 26 weeks. 15 patients received in addition the […]
Continuous dopaminergic stimulation by Duodopa in advanced Parkinson’s disease: Efficacy and safety
Annic, A.,
Devos, D.,
Seguy, D.,
Dujardin, K.,
Destée, A.,
Defebvre, L.
Introduction: When advanced Parkinson’s disease (PD) patients experience motor complications (fluctuations and dyskinesias) despite standard oral treatment, two treatment options are available: deep brain stimulation and subcutaneous apomorphine infusion with respects of indications for each strategy. Continuous intraduodenal infusion of levodopa (Duodopa) via a gastrojejunal tube may be proposed at this stage of the disease […]
Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment
Lippa, Carol F.,
Rosso, Andrea,
Hepler, Marjorie,
Jenssen, Sigmund,
Pillai, Jyoti,
Irwin, David
Cognitive impairment and seizures are common in our aging population. Anticonvulsant treatment is problematic due to sedation, cognitive slowing, and behavioral changes. Levetiracetam has favorable pharmacokinetics, good efficacy in elderly individuals, a favorable side effect profile, and lacks major drug interactions. We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to […]
A phase I trial of deep brain stimulation of memory circuits in Alzheimer’s disease
Laxton, Adrian W.,
Tang-Wai, David F.,
McAndrews, Mary Pat,
Zumsteg, Dominik,
Wennberg, Richard,
Keren, Ron,
Wherrett, John,
Naglie, Gary,
Hamani, Clement,
Smith, Gwenn S.,
Lozano, Andres M.
Objective: Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits.; Methods: We conducted a phase I trial in 6 patients with mild AD receiving […]
Technology-aided verbal instructions to help persons with mild or moderate Alzheimer’s disease perform daily activities
Lancioni, Giulio E.,
Singh, Nirbhay N.,
O’Reilly, Mark F.,
Sigafoos, Jeff,
Tatulli, Emanuela,
Rigante, Valeria,
Zonno, Nadia,
Perilli, Viviana,
Pinto, Katia,
Minervini, Mauro G.
These two studies extended previous research on the use of verbal instructions and support technology for helping persons with mild or moderate Alzheimer’s disease perform daily activities. Study I included seven participants who were to carry out one of two previously targeted activities (i.e., either coffee preparation or table setting). Study II included four participants […]
Evaluation of a brief educational program for dementia carers: the AENEAS study
Objective: To evaluate the efficacy of a practical, easily implemented, educational intervention in group format for informal carers of persons with dementia.; Methods: Multi-centre, randomised, controlled, single-blind trial involving 292 family caregivers of patients with moderate dementia in Alzheimer’s disease.; Results: Participants valued program components which had a practical impact on their caring role. The […]