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Levetiracetam: a practical option for seizure management in elderly patients with cognitive impairment


Lippa, Carol F., Rosso, Andrea, Hepler, Marjorie, Jenssen, Sigmund, Pillai, Jyoti, Irwin, David


American Journal Of Alzheimer's Disease And Other Dementias, Volume: 25, No.: 2, Pages.: 149-154

Year of Publication



Cognitive impairment and seizures are common in our aging population. Anticonvulsant treatment is problematic due to sedation, cognitive slowing, and behavioral changes. Levetiracetam has favorable pharmacokinetics, good efficacy in elderly individuals, a favorable side effect profile, and lacks major drug interactions. We conducted a prospective, uncontrolled, phase 4, open label, 12-week study of levetiracetam to better profile its efficacy, safety, and impact on cognitive/behavioral status in 24 cognitively impaired, elderly individuals. In total, 69% were seizure free for the duration of the study; the remaining participants had satisfactory seizure control. Fatigue was the most common side effect (5 participants). Significant overall improvements were observed for the Folstein’s Mini-Mental State Examination and the Alzheimer’s Disease Assessment Scale-Cognitive. No significant changes were seen in behavioral or functional measures. Levetiracetam is an effective antiepileptic drug in elderly individuals with cognitive impairment. At 3 months, participants who remained on levetiracetam showed excellent cognitive tolerability.;

Bibtex Citation

@article{Lippa_2008, doi = {10.1177/1533317508325095}, url = {}, year = 2008, month = {nov}, publisher = {{SAGE} Publications}, volume = {25}, number = {2}, pages = {149--154}, author = {C. F. Lippa and A. Rosso and M. Hepler and S. Jenssen and J. Pillai and D. Irwin}, title = {Levetiracetam: A Practical Option for Seizure Management in Elderly Patients With Cognitive Impairment}, journal = {American Journal of Alzheimer{textquotesingle}s Disease and Other Dementias} }


adverse effects, aged, aged, 80 and over, aging, analogs derivatives, anticonvulsant, anticonvulsants, chemically induced, cognition, cognition disorders, diseasefree survival, drug effects, drug therapy, fatigue, female, humans, male, middle aged, piracetam, prospective studies, psychiatric status rating scales, psychology, seizures, severity of illness index, therapeutic use, treatment outcome

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Randomised Controlled Trial

Type of Outcomes

Behaviour, Cognition

Type of Interventions

Treatment/prevention of co-morbidities or additional risks

Pharmaceutical Interventions