This database contains 366 studies, archived under the term: "methods"
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Memantine effects measured with the Relevant Outcome Scale for Alzheimer’s disease in an open-label, single-arm, multicenter clinical study
Holthoff, Vjera,
Ferris, Steven,
Gauthier, Serge,
Ihl, Ralf,
Robert, Philippe,
Winblad, Bengt,
Sternberg, Kati,
Tennigkeit, Frank
Objective: The Relevant Outcome Scale for Alzheimer’s disease (ROSA) is a novel, valid, and reliable instrument for multidimensional assessment of Alzheimer’s disease (AD) symptoms across all severity stages. The ROSA and four standard instruments — the Alzheimer’s disease Assessment Scale-cognitive (ADAS-cog), Severe Impairment Battery (SIB), Disability Assessment for Dementia (DAD), and the Neuropsychiatric Inventory (NPI) […]
Altered microstructure in corticospinal tract in idiopathic normal pressure hydrocephalus: comparison with Alzheimer disease and Parkinson disease with dementia
Hattori, T.,
Yuasa, T.,
Aoki, S.,
Sato, R.,
Sawaura, H.,
Mori, T.,
Mizusawa, H.
Background and Purpose: Previous neuropathologic studies in chronic hydrocephalus have suggested the presence of white matter damage, presumably from mechanical pressure due to ventricular enlargement and metabolic derangement. This study aimed to investigate the diffusional properties of the CST in patients with iNPH by using DTI and to determine whether this method could be used […]
Keeping up health promotion practices in specialized day care units for people with dementia
Background: Health promotion practices hold promises for elderly individuals’ quality of life. This article shows that such practices can be promoted in specialized day care units for individuals with dementia.; Method: Group interviews with 8 groups of staff (comprising 24 staff members) in 3 day care units.; Results: Rather than referring directly to health promotion […]
Plasma proteomics for the identification of Alzheimer disease
Less-invasive biomarkers for early Alzheimer disease (AD) are urgently needed. The present study aimed to establish a panel of plasma proteins that accurately distinguishes early AD from physiological aging and to compare the findings with previous reports. Fifty-eight healthy controls (CON) and 109 patients with AD dementia were randomly split into a training (40%) and […]
Evaluating proFamilies-dementia: adopting photovoice to capture clinical significance
Dementia is a challenging chronic illness that affects the patients and their families. Families often perform a full-time, specialised role, which requires expert knowledge and skills. This paper describes the evaluation of proFamilies-dementia (a programme developed to support families that care for a relative with dementia) using an innovative participatory methodology: photovoice, a qualitative method […]
Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline
Grundman, Michael,
Pontecorvo, Michael J.,
Salloway, Stephen P.,
Doraiswamy, P. Murali,
Fleisher, Adam S.,
Sadowsky, Carl H.,
Nair, Anil K.,
Siderowf, Andrew,
Lu, Ming,
Arora, Anupa K.,
Agbulos, Abigail,
Flitter, Matthew L.,
Krautkramer, Michael J.,
Sarsour, Khaled,
Skovronsky, Daniel M.,
Mintun, Mark A.
Florbetapir F18 has been approved by the Food and Drug Administration for in vivo assessment of amyloid pathology in patients undergoing evaluation for Alzheimer disease (AD). The aim of this study was to determine the impact of amyloid imaging on the diagnoses and management of patients undergoing evaluation for cognitive decline. Patients were recruited to […]
Telephone-based, cognitive-behavioral therapy for African American dementia caregivers with depression: initial findings
Glueckauf, Robert L.,
Davis, W. Shuford,
Willis, Floyd,
Sharma, Dinesh,
Gustafson, David J.,
Hayes, Jocelyn,
Stutzman, Mary,
Proctor, James,
Kazmer, Michelle M.,
Murray, Leticia,
Shipman, Judith,
McIntyre, Vera,
Wesley, Lonnie,
Schettini, Gabriel,
Xu, Jian,
Parfitt, Francine,
Graff-Radford, Neill,
Baxter, Cynthia,
Burnett, Kathleen,
Noël, La Tonya,
Haire, Kambria,
Springer, Jane
Objectives: Discuss initial findings of a randomized clinical trial comparing the effects of telephone-based and face-to-face (f-to-f) cognitive-behavioral therapy (CBT) on changes in caregiver (CG) burden, assistance support, depression, and health status for African American (AA) CGs with depression.; Design: Pilot study using a prepost, two-group design with 14 enrolled and randomized participants.; Measures: Subjective […]
Integrative cognitive-behavioral and spiritual counseling for rural dementia caregivers with depression
Glueckauf, Robert L.,
Davis, W. Shuford,
Allen, Kay,
Chipi, Patty,
Schettini, Gabriel,
Tegen, Lance,
Jian, Xu,
Gustafson, David J.,
Maze, Janet,
Mosser, Barbara,
Prescott, Susie,
Robinson, Fay,
Short, Cindy,
Tickel, Sandra,
VanMatre, Joyce,
DiGeronimo, Thomas,
Ramirez, Carmen
Objective: Discuss initial evaluation of a program for training faith community nurses (FCNs) to conduct cognitive-behavioral and spiritual counseling (CBSC) for rural dementia caregivers (CGs), and present 2 case studies on the use of CBSC for treating depression in this population.; Study Design: Pre-post evaluation of the effectiveness of CBSC training and a case study […]