This database contains 1231 studies, archived under the term: "humans"
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Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer’s disease
Troussière, Anne-Cécile,
Monaca Charley, Christelle,
Salleron, Julia,
Richard, Florence,
Delbeuck, Xavier,
Derambure, Philippe,
Pasquier, Florence,
Bombois, Stéphanie
Background: It is essential to detect and then treat factors that aggravate Alzheimer’s disease (AD). Here, we sought to determine whether or not continuous positive airway pressure (CPAP) therapy for sleep apnoea syndrome (SAS) slows the rate of cognitive decline in mild-to-moderate AD patients.; Methods: Between January 2003 and June 2011, we included consecutive, mild-to-moderate […]
Genetic variation in galectin-3 gene associates with cognitive function at old age
Trompet, Stella,
Jukema, Wouter,
Mooijaart, Simon P.,
Ford, Ian,
Stott, David J.,
Westendorp, Rudi G.J.,
de Craen, Anton J.M.
Inflammation plays an important role in the development of cognitive decline and dementia in old age. Galectin-3 is known for its role in acute and chronic inflammation. We assessed whether genetic variation in the LGALS3 gene, encoding for galectin-3, associates with cognitive function in the 5804 participants of the PROspective Study of Pravastatin in the […]
The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study
Trollor, Julian N.,
Smith, Evelyn,
Agars, Emmeline,
Kuan, Stacey A.,
Baune, Bernhard T.,
Campbell, Lesley,
Samaras, Katherine,
Crawford, John,
Lux, Ora,
Kochan, Nicole A.,
Brodaty, Henry,
Sachdev, Perminder
Inflammation may contribute to cognitive decline and dementia. This study examined the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor, serum amyloid A, tumour necrosis factor-α and vascular adhesion molecule-1) and cognitive function in 873 non-demented community-dwelling elderly participants aged 70-90 years. Regression analyses were performed […]
How Can we provide better services for demented nursing home residents suffering from apathy?
Treusch, Yvonne,
Jerosch, Daniela,
Majić, Tomislav,
Heinz, Andreas,
Gutzmann, Hans,
Rapp, Michael
Behavioural and psychological symptoms of Dementia include agitation, depression and apathy. Apathy is a common condition and a major challenge especially in nursing home residents. The development of a brief intervention for nursing home residents combining physical activation and reminiscence therapy in order to reactivating apathic residents and increasing their quality of life will be […]
Neuroimaging predictors of brain amyloidosis in mild cognitive impairment
Objective: To identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid-free.; Methods: The prediction model cohort included 62 MCI subjects screened with structural magnetic resonance imaging (MRI) and (11) […]
A randomized controlled pilot study to evaluate a technology platform for the assisted living of people with dementia and their carers
Torkamani, Mariam,
McDonald, Louise,
Saez Aguayo, Ignasi,
Kanios, Christos,
Katsanou, Maria-Nefeli,
Madeley, Laura,
Limousin, Patricia D.,
Lees, Andrew J.,
Haritou, Maria,
Jahanshahi, Marjan
The use of telemedicine is becoming increasingly popular in assisting with the home management of People with Dementia (PwD) by offering services to the carers that may enhance their ability to care for their relative for longer. A computerized platform, ALADDIN, was evaluated in its usefulness to reduce carer burden and distress and to improve […]
Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients
Tikka, S.,
Mykkanen, K.,
Ruchoux, M.-M.,
Bergholm, R.,
Junna, M.,
Poyhonen, M.,
Yki-Jarvinen, H.,
Joutel, A.,
Viitanen, M.,
Baumann, M.,
Kalimo, H.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary subcortical vascular dementia. It is caused by mutations in NOTCH3 gene, which encodes a large transmembrane receptor Notch3. The key pathological finding is the accumulation of granular osmiophilic material (GOM), which contains extracellular domains of Notch3, on degenerating vascular smooth […]
MRI sequence findings in sporadic Creutzfeldt-Jakob disease
MRI has had an important role in the diagnosis of Creutzfeldt-Jakob disease (CJD). The aim of our study was to compare the efficacy of different MRI sequences among six biopsy-proven patients with sporadic CJD (sCJD) and seven patients with probable sCJD. These 13 patients with CJD aged from 36 years to 75 years (mean age: […]
The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: a pilot study
Thompson, J. A.,
Cruickshank, T. M.,
Penailillo, L. E.,
Lee, J. W.,
Newton, R. U.,
Barker, R. A.,
Ziman, M. R.
Background and Purpose: Despite advances in the understanding of Huntington’s disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD.; Methods: Twenty patients with HD were assigned to two […]