This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: a pilot study


Thompson, J. A., Cruickshank, T. M., Penailillo, L. E., Lee, J. W., Newton, R. U., Barker, R. A., Ziman, M. R.


European Journal Of Neurology: The Official Journal Of The European Federation Of Neurological Societies, Volume: 20, No.: 9, Pages.: 1325-1329

Year of Publication



Background and Purpose: Despite advances in the understanding of Huntington’s disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD.; Methods: Twenty patients with HD were assigned to two groups, equally matched for cognitive and motor scores. One group received the intervention, whilst the other served as control. The Unified-Huntington’s-Disease-Rating-Scale-Total-Motor-Score was the primary outcome measure. Neurocognitive/psychological tests, body composition, postural stability, strength and quality of life assessments were secondary outcome measures.; Results: The intervention reduced motor and postural stability deterioration, with minor improvements in depression, cognition and quality of life. Significant gains were observed for fat-free mass and strength.; Conclusion: This pilot study suggests that a prolonged multidisciplinary rehabilitation programme in early-to-middle-stage HD is feasible, well-tolerated and associated with therapeutic benefit. Further explorative, larger studies are warranted.; © 2012 The Author(s) European Journal of Neurology © 2012 EFNS.

Bibtex Citation

@article{Thompson_2012, doi = {10.1111/ene.12053}, url = {}, year = 2012, month = {dec}, publisher = {Wiley-Blackwell}, volume = {20}, number = {9}, pages = {1325--1329}, author = {J. A. Thompson and T. M. Cruickshank and L. E. Penailillo and J. W. Lee and R. U. Newton and R. A. Barker and M. R. Ziman}, title = {The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington{textquotesingle}s disease: a pilot study}, journal = {Eur J Neurol} }


and, chorea, exercise therapy, female, functioning, humans, huntington disease, male, methods, middle aged, motor, multidiscplinary, neurodegenerative, occupational therapy, pilot projects, posture, programme, rehabilitation, resistance training, treatment outcome, unifiedhuntingtonsdiseaseratingscaletotalmotorscore

Countries of Study


Types of Dementia


Types of Study

Non randomised controlled trial

Type of Outcomes

Physical Health

Type of Interventions

Non-pharmacological Treatment, Treatment/prevention of co-morbidities or additional risks

Non-Pharmaceutical Interventions