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This database contains 1231 studies, archived under the term: "humans"

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FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer’s disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the […]

Effect of three-line puncture on the Governor Vessel and Bladder Meridian on head on cognitive function of vascular dementia patients
Objective: To verify the therapeutic effect of vascular dementia treated with three-line puncture on the Governor Vessel and Bladder Meridian on head.; Methods: Sixty cases were randomly divided into a head-line puncture group and a routine acupuncture group, 30 cases in each group. In head-line puncture group, line puncture was applied on three lines of […]

Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study
Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function.; Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five […]

Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial
Cost-effective strategies to maintain healthy active lifestyle in aging populations are required to address the global burden of age-related diseases. ASPREE will examine whether the potential primary prevention benefits of low dose aspirin outweigh the risks in older healthy individuals. Our primary hypothesis is that daily oral 100 mg enteric-coated aspirin will extend a composite […]

The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial
Background: Hip fractures mainly affect older people. It is associated with high morbidity and mortality, and in particular a high frequency of delirium. Incident delirium following hip fracture is associated with an increased risk of dementia in the following months, but it is still not firmly established whether this is an association or a causal […]

Differences in verbal memory performance in postmenopausal women receiving hormone therapy: 17β-estradiol versus conjugated equine estrogens
Objective: Much controversy exists and many questions remain unanswered about the effects of hormone therapy (HT) on cognition in postmenopausal women. There is growing evidence suggesting that HT compounds containing conjugated equine estrogen (CEE) have negative effects on cognition whereas 17β-estradiol (17β-E) either has positive or neutral effects. The present study sought to further examine […]

Preventing disruptive behavior of nursing home residents
Disruptive behavior is an increasing challenge for professional care in nursing homes. It frequently accompanies dementia, which is one of the most common chronic illnesses among the residents. Nursing homes are, therefore, subject to a high accumulation of problems due to behavior with risk potential. However, usual nursing interventions are often limited to restrictions in […]

Nursing home care for people with dementia and residents’ quality of life, quality of care and staff well-being: design of the Living Arrangements for people with Dementia (LAD)-study
Background: There is limited information available on how characteristics of the organization of nursing home care and especially group living home care and staff ratio contribute to care staff well being, quality of care and residents’ quality of life. Furthermore, it is unknown what the consequences of the increasingly small scale organization of care are […]

The effects of ramipril in individuals at risk for Alzheimer’s disease: results of a pilot clinical trial
Research shows that certain antihypertensives taken during midlife confer Alzheimer’s disease (AD) related benefits in later life. We conducted a clinical trial to evaluate the extent to which the angiotensin converting enzyme inhibitor (ACE-I), ramipril, affects AD biomarkers including cerebrospinal fluid (CSF) amyloid-β (Aβ) levels and ACE activity, arterial function, and cognition in participants with […]

Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]

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