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Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study


Yasar, Sevil, Lin, Fu-Mei, Fried, Linda P., Kawas, Claudia H., Sink, Kaycee M., DeKosky, Steven T., Carlson, Michelle C.


Alzheimer's & Dementia: The Journal Of The Alzheimer's Association, Volume: 8, No.: 3, Pages.: 188-195

Year of Publication



Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function.; Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five cognitive domains were assessed. Multivariate linear regression analyses were used to assess cross-sectional associations between medication use and cognitive function.; Results: In all, 36% of participants reported history of hypertension and 53% reported antihypertensive medication use, with 17% reporting diuretic, 11% ACE-I, and 2% AT2RB use. Potassium-sparing diuretic use (N = 192) was associated with better verbal learning and memory measured by California Verbal Learning Test as compared with no antihypertensive medication users (β = 0.068, P = .01; β = 0.094, P < .001) and other antihypertensive medication users (β = 0.080, P = .03; β = 0.153, P < .001). Use of ACE-I or AT2RB was not associated with better cognitive function.; Conclusion: Results warrant further investigation into possible protective effects of potassium-sparing diuretics and the role of potassium in mitigating cognitive decline.; Copyright © 2012 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Bibtex Citation

@article{Yasar_2012, doi = {10.1016/j.jalz.2011.03.010}, url = {}, year = 2012, month = {may}, publisher = {Elsevier {BV}}, volume = {8}, number = {3}, pages = {188--195}, author = {Sevil Yasar and Fu-Mei Lin and Linda P. Fried and Claudia H. Kawas and Kaycee M. Sink and Steven T. DeKosky and Michelle C. Carlson}, title = {Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory study}, journal = {Alzheimer{textquotesingle}s {&} Dementia} }


aged, aged, 80 and over, angiotensin receptor antagonists, dementia, diuretics, doubleblind method, drug effects, drug therapy, female, ginkgo biloba, humans, hypertension, learning, linear models, longitudinal studies, male, memory, mental status schedule, methods, neuropsychological tests, pharmacology, phytotherapy, prevention & control, residence characteristics, therapeutic use, treatment outcome

Countries of Study


Types of Study

Cohort Study

Type of Outcomes




Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion