This database contains 1231 studies, archived under the term: "humans"
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Mental and physical activities delay cognitive decline in older persons with dementia
Cheng, Sheung-Tak,
Chow, Pizza K.,
Song, You-Qiang,
Yu, Edwin C.S.,
Chan, Alfred C.M.,
Lee, Tatia M.C.,
Lam, John H.M.
Objectives: To examine the effects of cognitive stimulation (mahjong) and physical exercise (tai chi [TC]) on cognitive performance in persons with dementia.; Design: Cluster-randomized open-label controlled design.; Setting: Nursing homes.; Participants: One hundred ten residents, most of whom were cholinesterase-inhibitor naive. Inclusion criteria were Mini-Mental State Examination (MMSE) = 10-24 and suffering from at least very mild […]
Women have farther to fall: gender differences between normal elderly and Alzheimer’s disease in verbal memory engender better detection of Alzheimer’s disease in women
Chapman, Robert M.,
Mapstone, Mark,
Gardner, Margaret N.,
Sandoval, Tiffany C.,
McCrary, John W.,
Guillily, Maria D.,
Reilly, Lindsey A.,
DeGrush, Elizabeth
We analyzed verbal episodic memory learning and recall using the Logical Memory (LM) subtest of the Wechsler Memory Scale-III to determine how gender differences in AD compare to those seen in normal elderly and whether or not these differences impact assessment of AD. We administered the LM to both an AD and a Control group, […]
The effect of midlife physical activity on cognitive function among older adults: AGES–Reykjavik Study
Chang, M.,
Jonsson, P. V.,
Snaedal, J.,
Bjornsson, S.,
Saczynski, J. S.,
Aspelund, T.,
Eiriksdottir, G.,
Jonsdottir, M. K.,
Lopez, O. L.,
Harris, T. B.,
Gudnason, V.,
Launer, L. J.
Background: There are few studies on the long-term associations of physical activity (PA) to cognition. Here, we examine the association of midlife PA to late-life cognitive function and dementia.; Methods: The sample consisted of a population-based cohort of men and women (born in 1907-1935) participating in the Age Gene/Environment Susceptibility-Reykjavik Study. The interval between the […]
Continuous use of antipsychotics and its association with mortality and hospitalization in institutionalized Chinese older adults: an 18-month prospective cohort study
Chan, Tuen-Ching,
Luk, James Ka-Hay,
Shea, Yat-Fung,
Lau, Ka-Hin,
Chan, Felix Hon-Wai,
Yu, Gabriel Ka-Kui,
Chu, Leung-Wing
Background: Previous meta-analyses have suggested that antipsychotics are associated with increased mortality in dementia patients with behavioral and psychological symptoms (BPSD). Subsequent observational studies, however, have produced conflicting results. In view of this controversy and the lack of any suitable pharmacological alternative for BPSD, this study aimed to investigate the relationship between continuous use of […]
Training needs and evaluation of a neuro-HIV training module for non-physician healthcare workers in western Kenya
Cettomai, Deanna,
Kwasa, Judith,
Birbeck, Gretchen L.,
Price, Richard W.,
Bukusi, Elizabeth A.,
Meyer, Ana-Claire
Background: Recent efforts to improve neurological care in resource-limited settings have focused on providing training to non-physician healthcare workers.; Methods: A one-day neuro-HIV training module emphasizing HIV-associated dementia (HAD) and peripheral neuropathy was provided to 71 health care workers in western Kenya. Pre- and post-tests were administered to 55 participants.; Results: Mean age of participants […]
Effect of cognitive training on the expression of brain-derived neurotrophic factor in lymphocytes of mild cognitive impairment patients
Casoli, Tiziana,
Giuli, Cinzia,
Balietti, Marta,
Giorgetti, Belinda,
Solazzi, Moreno,
Fattoretti, Patrizia
To identify biomarkers associated with cognitive stimulation of mild cognitive impairment (MCI) patients, we performed quantitative real-time reverse transcriptase polymerase chain reaction for brain-derived neurotrophic factor (BDNF) mRNA in peripheral lymphocytes of MCI and healthy subjects undergoing a multi-component cognitive training (CT) program. CT determined a significant decrease of BDNF mRNA levels in MCI (fold […]
The mini-mental Parkinson’s (MMP) as a cognitive screening tool in people with Parkinson’s disease
Caslake, Robert,
Summers, Fiona,
McConachie, Douglas,
Ferris, Catriona,
Gordon, Joanna,
Harris, Clare,
Caie, Linda,
Counsell, Carl
Background: Cognitive decline is common in Parkinson’s disease (PD) but may not be adequately identified by the mini-mental state examination (MMSE), which is better suited to Alzheimer’s disease. The mini-mental Parkinson (MMP) examination is a cognitive screening tool designed in French specifically for PD. We aimed to establish the validity and reliability of the English […]
Safety and effectiveness of donepezil on behavioral symptoms in patients with Alzheimer disease
The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to […]