This database contains 283 studies, archived under the term: "diagnosis"
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Differential effects of global and cerebellar normalization on detection and differentiation of dementia in FDG-PET studies
Dukart, Juergen,
Mueller, Karsten,
Horstmann, Annette,
Vogt, Barbara,
Frisch, Stefan,
Barthel, Henryk,
Becker, Georg,
Möller, Harald E.,
Villringer, Arno,
Sabri, Osama,
Schroeter, Matthias L.
FDG-PET ([18F]fluorodeoxyglucose positron emission tomography) is frequently used to improve the differential diagnosis of dementia. However, a fundamental methodological issue of the reference area for the intensity normalization procedure is still unsolved. Here, we systematically compared the two most commonly used normalization methods to the cerebral and to the cerebellar metabolic rate for glucose with […]
Quality of life in nursing home residents with advanced dementia
Objectives: To examine quality of life (QOL) in nursing home (NH) residents with advanced dementia and identify correlates of QOL near the end of life.; Design: Cross-sectional data derived from NH records, interviews with residents’ surrogate decision-makers, QOL ratings by NH caregivers, and assessment of residents’ cognitive function.; Setting: Three NHs in Maryland.; Participants: A […]
Subjective report of word-finding and memory deficits in normal aging and dementia
Calley, Clifford S.,
Tillman, Gail D.,
Womack, Kyle,
Moore, Patricia,
Hart, John, Jr.,
Kraut, Michael A.
Objective: Compare subjective reports of both memory and word-finding deficits to clinical diagnosis and objective neuropsychological testing.; Background: With the increasing number of aging individuals with cognitive impairments, effective screening measures would improve the likelihood of detection. Subjective reports of symptoms are typically obtained in clinical settings, yet the validity of these reports is relatively […]
Autoimmune dementia: clinical course and predictors of immunotherapy response
Flanagan, Eoin P.,
McKeon, Andrew,
Lennon, Vanda A.,
Boeve, Bradley F.,
Trenerry, Max R.,
Tan, K. Meng,
Drubach, Daniel A.,
Josephs, Keith A.,
Britton, Jeffrey W.,
Mandrekar, Jayawant N.,
Lowe, Val,
Parisi, Joseph E.,
Pittock, Sean J.
Objective: To define the diagnostic characteristics and predictors of treatment response in patients with suspected autoimmune dementia.; Patients and Methods: Between January 1, 2002, and January 1, 2009, 72 consecutive patients received immunotherapy for suspected autoimmune dementia. Their baseline clinical, radiologic, and serologic characteristics were reviewed and compared between patients who were responsive to immunotherapy […]
The OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation
Underwood, Martin,
Eldridge, Sandra,
Lamb, Sallie,
Potter, Rachel,
Sheehan, Bartley,
Slowther, Anne-Marie,
Taylor, Stephanie,
Thorogood, Margaret,
Weich, Scott
Background: Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve outcomes among younger and older people. Existing evidence comes from […]
Feasibility study of an optimised person-centred intervention to improve mental health and reduce antipsychotics amongst people with dementia in care homes: study protocol for a randomised controlled trial
Whitaker, Rhiannon,
Ballard, Clive,
Stafford, Jane,
Orrell, Martin,
Moniz-Cook, Esme,
Woods, Robert T,
Murray, Joanna,
Knapp, Martin,
Carlton, Barbara Woodward,
Fossey, Jane
Background: People living in care homes often have complex mental and physical health problems, disabilities and social needs which are compounded by the use of psychiatric and other drugs. In the UK dementia care is a national priority with a vast impact on services. WHELD combines the most effective elements of existing approaches to develop […]
Self-management in early-stage dementia: a pilot randomised controlled trial of the efficacy and cost-effectiveness of a self-management group intervention (the SMART study)
Quinn, Catherine,
Anderson, Daniel,
Toms, Gill,
Whitaker, Rhiannon,
Edwards, Rhiannon Tudor,
Jones, Carys,
Clare, Linda
Background: The possibility of living well with a long-term condition has been identified as centrally relevant to the needs of people living with dementia. Growing numbers of people with early-stage dementia are contributing accounts that emphasise the benefits of actively engaging in managing the condition. Self-management interventions share the common objectives of educating about the […]
Does telecare prolong community living in dementia? A study protocol for a pragmatic, randomised controlled trial
Leroi, Iracema,
Woolham, John,
Gathercole, Rebecca,
Howard, Robert,
Dunk, Barbara,
Fox, Chris,
O'Brien, John,
Bateman, Andrew,
Poland, Fiona,
Bentham, Peter,
Burns, Alistair,
Davies, Anna,
Forsyth, Kirsty,
Gray, Richard,
Knapp, Martin,
Newman, Stanton,
McShane, Rupert,
Ritchie, Craig
Background: Assistive technology and telecare (ATT) are relatively new ways of delivering care and support to people with social care needs. It is claimed that ATT reduces the need for community care, prevents unnecessary hospital admission, and delays or prevents admission into residential or nursing care. The current economic situation in England has renewed interest […]