Lautenschlager, Nicola T., Cox, Kay L., Flicker, Leon, Foster, Jonathan K., van Bockxmeer, Frank M., Xiao, Jianguo, Greenop, Kathryn R., Almeida, Osvaldo P.

Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]

Diamond, Keri, Mowszowski, Loren, Cockayne, Nicole, Norrie, Louisa, Paradise, Matthew, Hermens, Daniel F., Lewis, Simon J. G., Hickie, Ian B., Naismith, Sharon L.

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]

Okonkwo, O. C., Schultz, S. A., Oh, J. M., Larson, J., Edwards, D., Cook, D., Koscik, R., Gallagher, C. L., Dowling, N. M., Carlsson, C. M., Bendlin, B. B., LaRue, A., Rowley, H. A., Christian, B. T., Asthana, S., Hermann, B. P., Johnson, S. C., Sager, M. A.

Objective: To examine whether engagement in physical activity might favorably alter the agedependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a cohort of at-risk, late-middle-aged adults. Methods: Three hundred seventeen enrollees in the Wisconsin Registry for Alzheimer’s Prevention underwent T1 MRI; a subset also underwent ¹¹C-Pittsburgh compound B–PET (n = 186) and […]

Rasgon, Natalie L., Geist, Cheri L., Kenna, Heather A., Wroolie, Tonita E., Williams, Katherine E., Silverman, Daniel H. S.

The objective of this study was to examine the effects of estrogen-based hormone therapy (HT) on regional cerebral metabolism in postmenopausal women (mean age = 58, SD = 5) at risk for development of dementia. The prospective clinical trial design included pre- and post-intervention neuroimaging of women randomized to continue (HT+) or discontinue (HT2) therapy […]

Neville, Charlotte E., McCourt, Hannah J., McKinley, Michelle C., Lowis, Carole, Barrett, Suzanne L., McGuinness, Bernadette, Todd, Stephen, Lawlor, Brian, Gibb, Matthew, Coen, Robert F., Passmore, Anthony P., Woodside, Jayne V.

Objectives: A healthy lifestyle may help maintain cognitive function and reduce the risk of developing dementia. This study employed a focus group approach in order to gain insight into opinions of mild cognitive impairment (MCI) patients, caregivers (CG) and health professionals (HP) regarding lifestyle and its relationship with cognition. The qualitative data were used to […]

Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]