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Risk of cerebrovascular accident associated with use of antipsychotics: population-based case-control study
Laredo, Leonor,
Vargas, Emilio,
Blasco, Antonio Javier,
Aguilar, Maria Dolores,
Moreno, Alfonso,
Portolés, Antonio
Objectives: To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older.; Design: Population-based case-control study.; Setting: UK-based electronic primary care records in the General Practice Research Database (GPRD).; Participants: Individuals with dementia aged 65 and older registered in the database between January 1, […]
Technology-based orientation programs to support indoor travel by persons with moderate Alzheimer’s disease: impact assessment and social validation
Lancioni, Giulio E.,
Perilli, Viviana,
O’Reilly, Mark F.,
Singh, Nirbhay N.,
Sigafoos, Jeff,
Bosco, Andrea,
Caffò, Alessandro O.,
Picucci, Luciana,
Cassano, Germana,
Groeneweg, Jop
The present study (a) extended the assessment of an orientation program involving auditory cues (i.e., verbal messages automatically presented from the destinations) with five patients with Alzheimer’s disease, (b) compared the effects of this program with those of a program with light cues (i.e., a program in which strobe lights were used instead of the […]
What effect does a structured home-based exercise programme have on people with Huntington’s disease? A randomized, controlled pilot study
Khalil, H.,
Quinn, L.,
van Deursen, R.,
Dawes, H.,
Playle, R.,
Rosser, A.,
Busse, M.
Objective: The aim of this study was to explore feasibility, safety and outcome of an exercise intervention in people with Huntington’s disease.; Design: A randomized controlled pilot trial.; Setting: A home-based exercise programme.; Subjects: A total of 25 subjects with early to mid-stage Huntington’s disease.; Intervention: Subjects were randomly allocated to either an exercise intervention […]
Effect of shunt operation on idiopathic normal pressure hydrocephalus patients in reducing caregiver burden: evidence from SINPHONI
Kazui, Hiroaki,
Mori, Etsuro,
Hashimoto, Masaaki,
Ishikawa, Masatsune,
Hirono, Nobutsugu,
Takeda, Masatoshi
Background/aims: Patients with idiopathic normal pressure hydrocephalus (iNPH) are often given shunt operations to reduce the triad symptoms (cognitive impairment, gait disturbance and urinary disturbance). We examined whether they also reduce caregiver burden.; Methods: The personal strain (PS) and role strain (RS) factors, which are related to the stress and constraints, respectively, on the caregivers […]
A home-based training program improves caregivers’ skills and dementia patients’ aggressive behaviors: a randomized controlled trial
Huang, Huei-Ling,
Kuo, Li-Min,
Chen, Yu-Shu,
Liang, Jersey,
Huang, Hsiu-Li,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Sun, Yu,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objective: To investigate the effects of an individualized, home-based caregiver-training program for caregivers of elderly patients with dementia and behavioral problems.; Methods: Using a randomized clinical trial in the neurologic clinics of two hospitals and a community care management center in northern Taiwan, we tested an individualized home-based caregiver-training program for managing behavioral problems, with […]
Time until incident dementia among Medicare beneficiaries using centrally acting or non-centrally acting ACE inhibitors
Hebert, Paul L.,
McBean, Alexander Marshall,
O'Connor, Heidi,
Frank, Barbara,
Good, Charles,
Maciejewski, Matthew L.
Background: Centrally active (CA) angiotensin-converting enzyme inhibitors (ACEIs) are able to cross the blood–brain barrier. Small observational studies and mouse models suggest that use of CA versus non-CA ACEIs is associated with a reduced incidence of Alzheimer’s disease and related dementias (ADRD).; Objective: The aim of this research was to assess the effect of CA […]