This database contains 58 studies, archived under the term: "analysis of variance"
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A phase II trial of huperzine A in mild to moderate Alzheimer disease
Rafii, M. S.,
Walsh, S.,
Little, J. T.,
Behan, K.,
Reynolds, B.,
Ward, C.,
Jin, S.,
Thomas, R.,
Aisen, P. S.
Objective: Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD).; Methods: We assessed the safety, tolerability, and efficacy of huperzine A in mild to moderate AD in a multicenter trial in which 210 […]
SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study
Maher-Edwards, Gareth,
Dixon, Ruth,
Hunter, Jackie,
Gold, Michael,
Hopton, Gillian,
Jacobs, Gemma,
Hunter, Jo,
Williams, Pauline
Objective: To estimate the treatment effects of SB-742457 and donepezil in Alzheimer disease (AD) in a contemporary clinical trial.; Method: Randomized, controlled, parallel-group, exploratory study with a 4-week, single-blind, placebo run-in phase and 24-week, double-blind treatment phase. Primary endpoints were Clinician’s Interview-Based Impression of Change with caregiver input (CIBIC+) and the Alzheimer’s Disease Assessment Scale-cognitive […]
Improved social interaction and increased anterior cingulate metabolism after group reminiscence with reality orientation approach for vascular dementia
Akanuma, Kyoko,
Meguro, Kenichi,
Meguro, Mitsue,
Sasaki, Eriko,
Chiba, Kentaro,
Ishii, Hiroshi,
Tanaka, Naofumi
A group reminiscence approach (GRA) with reality orientation (RO) is widely used as a psychosocial intervention for dementia. Since clinical effectiveness was reported for the intervention, interest has been directed toward areas of the neuronal network that might be being stimulated. We hypothesized that the frontal lobe associated with social interaction was being stimulated. To […]
Phenserine efficacy in Alzheimer’s disease
Winblad, Bengt,
Giacobini, Ezio,
Frölich, Lutz,
Friedhoff, Lawrence T.,
Bruinsma, Gosse,
Becker, Robert E.,
Greig, Nigel H.
To gather preliminary evidence in Alzheimer’s disease (AD) for the efficacy of phenserine, a non-competitive acetylcholinesterase inhibitor that has independent modulatory effects on amyloid-β generation, a 12-week comparison of patients receiving phenserine (10 and 15 mg BID) or placebo was conducted under double-blind conditions. Patients who completed 12 weeks of the double-blind before others were […]
The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer’s disease
Wiig, E. H.,
Annas, P.,
Basun, H.,
Andreasen, N.,
Lannfelt, L.,
Zetterberg, H.,
Blennow, K.,
Minthon, L.
Objectives: To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer’s disease (AD).; Materials and Methods: Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A […]
Music as a memory enhancer in patients with Alzheimer’s disease
Musical mnemonics have a long and diverse history of popular use. In addition, music processing in general is often considered spared by the neurodegenerative effects of Alzheimer’s disease (AD). Research examining these two phenomena is limited, and no work to our knowledge has explored the effectiveness of musical mnemonics in AD. The present study sought […]