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Improved social interaction and increased anterior cingulate metabolism after group reminiscence with reality orientation approach for vascular dementia


Akanuma, Kyoko, Meguro, Kenichi, Meguro, Mitsue, Sasaki, Eriko, Chiba, Kentaro, Ishii, Hiroshi, Tanaka, Naofumi


Psychiatry Research, Volume: 192, No.: 3, Pages.: 183-187

Year of Publication



A group reminiscence approach (GRA) with reality orientation (RO) is widely used as a psychosocial intervention for dementia. Since clinical effectiveness was reported for the intervention, interest has been directed toward areas of the neuronal network that might be being stimulated. We hypothesized that the frontal lobe associated with social interaction was being stimulated. To test this hypothesis, we studied 24 patients with vascular dementia. In addition to conventional care, a 1-h session of GRA with RO was provided once a week for 3 months in the GRA-RO arm (n=12). Only supportive care was provided in the control arm (n=12). Before and after the interventions, cognitive function, depressive state, and social activities were assessed. Since glucose metabolism is associated with brain function, cerebral glucose metabolism was measured by positron emission tomography (PET). Regarding behavioral improvement, 10 patients in the GRA-RO arm showed improvement compared with only two patients in the control arm, a significant difference. PET demonstrated that metabolism in the anterior cingulate was increased in the GRA-RO arm, whereas no significant changes were observed in the control arm. These results suggest that GRA-RO stimulates the anterior cingulate and has a positive effect on social interaction.; Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Bibtex Citation

@article{Akanuma_2011, doi = {10.1016/j.pscychresns.2010.11.012}, url = {}, year = 2011, month = {jun}, publisher = {Elsevier {BV}}, volume = {192}, number = {3}, pages = {183--187}, author = {Kyoko Akanuma and Kenichi Meguro and Mitsue Meguro and Eriko Sasaki and Kentaro Chiba and Hiroshi Ishii and Naofumi Tanaka}, title = {Improved social interaction and increased anterior cingulate metabolism after group reminiscence with reality orientation approach for vascular dementia}, journal = {Psychiatry Research: Neuroimaging} }


activities, aged, analysis of variance, brain mapping, cognition, dementia vascular, diagnostic use, female, fluorodeoxyglucose f18, gyrus cinguli, humans, interpersonal relations, japan, male, mental status schedule, metabolism, methods, middle aged, orientation, pathology, physiology, psychology, radionuclide imaging, reality therapy, rehabilitation, social, tomography emissioncomputed

Countries of Study


Types of Dementia

Vascular Dementia

Types of Study

Non randomised controlled trial

Type of Outcomes

Cognition, Depression and Anxiety, Other

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention, Reminiscence and Anxiety Therapies