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This database contains 750 studies, archived under the term: "aged, 80 and over"

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Risk of cerebrovascular accident associated with use of antipsychotics: population-based case-control study
Objectives: To explore the association between use of antipsychotics and risk of cerebrovascular accident (CVA) in individuals with dementia aged 65 and older.; Design: Population-based case-control study.; Setting: UK-based electronic primary care records in the General Practice Research Database (GPRD).; Participants: Individuals with dementia aged 65 and older registered in the database between January 1, […]

Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial
Background: Little is known about the effect of methylphenidate (MPH) on attention in Alzheimer’s disease (AD). MPH has shown to improve apathy in AD, and both apathy and attention have been related to dopaminergic function. The goal was to investigate MPH effects on attention in AD and assess the relationship between attention and apathy responses.; […]

Self-regulated music stimulation for persons with Alzheimer’s disease: impact assessment and social validation
Objective: To assess the impact and the social rating of an active music condition (in which 10 patients with Alzheimer’s disease regulated their music input) vs. a passive music condition.; Method: In the active condition, the patients used a simple hand response and a microswitch to activate music stimulation periods. In the passive condition, music […]

Technology-based orientation programs to support indoor travel by persons with moderate Alzheimer’s disease: impact assessment and social validation
The present study (a) extended the assessment of an orientation program involving auditory cues (i.e., verbal messages automatically presented from the destinations) with five patients with Alzheimer’s disease, (b) compared the effects of this program with those of a program with light cues (i.e., a program in which strobe lights were used instead of the […]

Assessing the impact and social perception of self-regulated music stimulation with patients with Alzheimer’s disease
We assessed the impact and social rating of an active and a passive music condition implemented with six patients with Alzheimer’s disease. In the active condition, the patients used a simple hand response and a microswitch to self-regulate music stimulation inputs. In the passive condition, music stimulation was automatically presented throughout the sessions. Active and […]

Modality of physical exercise and cognitive function in Hong Kong older Chinese community
Objective: We reported the association between modality of Physical Exercise and cognitive function in 782 older Chinese adults assessed in the second phase of a population survey for dementia in Hong Kong.; Methods: Profiles of physical exercise was measured by a questionnaire (no exercise, stretching, aerobic and mind-body exercise). Cognitive Assessments included the CMMSE, ADAS-Cog, […]

A randomized controlled trial to examine the effectiveness of case management model for community dwelling older persons with mild dementia in Hong Kong
Objective: To evaluate a case management (CM) model for people with mild dementia, whereby resources within the family and in the community were mobilized and optimally used.; Method: Community dwelling psychiatric and geriatrics outpatients with mild dementia were randomized to receive CM by a trained occupational therapist for 4 months (CM group, N = 59) […]

Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan
This study investigated whether an association exists between irritable bowel syndrome (IBS) and the risk of Parkinson’s disease. This is a retrospective cohort study using the dataset of the Taiwan National Health Insurance Program from 2000 to 2010. We identified 23,875 patients (aged 20 years or older) with newly diagnosed IBS as the IBS group […]

Language-enriched exercise plus socialization for older adults with dementia: translation to rural communities
Interventions that stimulate and engage individuals with dementia physically, cognitively, and socially offer promise for improving health and well-being and for potentially slowing functional losses with disease progression. We describe a volunteer-based intervention that combines physical exercise, cognitive-linguistic stimulation, and social outings for older persons living with dementia in rural communities. One-year follow-up data, although […]

A multicenter, open-label, 24-week follow-up study for efficacy on cognitive function of donepezil in Binswanger-type subcortical vascular dementia
Objectives: To evaluate the efficacy and tolerability of donepezil in patients with Binswanger type subcortical vascular dementia.; Methods: Patients (n = 34, mean age = 71.8 + 7.12) with Binswanger type subcortical vascular dementia from 8 multicenter, according to clinical and neuroradiological working criteria, were selected to receive donepezil 5 mg/day (n = 2) or […]

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