This database contains 139 studies, archived under the term: "adult"
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Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial
Ooms, Sharon,
Overeem, Sebastiaan,
Besse, Kees,
Rikkert, Marcel Olde,
Verbeek, Marcel,
Claassen, Jurgen A. H. R.
Importance: Increasing evidence suggests a relationship between poor sleep and the risk of developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ), which is a key protein in Alzheimer disease pathology.; Objective: To determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in […]
Improving access to dementia care: development and evaluation of a rural and remote memory clinic
Morgan, Debra G.,
Crossley, Margaret,
Kirk, Andrew,
D’Arcy, Carl,
Stewart, Norma,
Biem, Jay,
Forbes, Dorothy,
Harder, Sheri,
Basran, Jenny,
Dal Bello-Haas, Vanina,
McBain, Lesley
The availability, accessibility and acceptability of services are critical factors in rural health service delivery. In Canada, the aging population and the consequent increase in prevalence of dementia challenge the ability of many rural communities to provide specialized dementia care. This paper describes the development, operation and evaluation of an interdisciplinary memory clinic designed to […]
In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
Mathis, Chester A.,
Kuller, Lewis H.,
Klunk, William E.,
Snitz, Beth E.,
Price, Julie C.,
Weissfeld, Lisa A.,
Rosario, Bedda L.,
Lopresti, Brian J.,
Saxton, Judith A.,
Aizenstein, Howard J.,
McDade, Eric M.,
Kamboh, M. Ilyas,
DeKosky, Steven T.,
Lopez, Oscar L.
Objective: This study examined amyloid-β (Aβ) deposition in 190 nondemented subjects aged ≥82 years to determine the proportion of Aβ-positive scans and associations with cognition, apolipoprotein E (APOE) status, brain volume, and Ginkgo biloba (Gb) treatment.; Methods: Subjects who agreed to participate had a brain magnetic resonance imaging and positron emission tomography scan with (11) […]
Maintenance of health and relief for caregivers of elderly with dementia by using “initial case management”: experiences from the Lighthouse Project on Dementia, Ulm, ULTDEM-study
Lukas, A.,
Kilian, R.,
Hay, B.,
Muche, R.,
von Arnim, C.A.F.,
Otto, M.,
Riepe, M.,
Jamour, M.,
Denkinger, M.D.,
Nikolaus, T.
Background: When facing the well-known demographic development with an increasing number of people suffering from dementia, there is a need of programmes to support nursing relatives and care at home. Many support services have been established in the past few years but they are rarely used by the relatives and the patients. The purpose of […]
Clinical effectiveness of a manual based coping strategy programme (START, STrAtegies for RelaTives) in promoting the mental health of carers of family members with dementia: pragmatic randomised controlled trial
Livingston, G.,
Barber, J.,
Rapaport, P.,
Knapp, M.,
Griffin, M.,
King, D.,
Livingston, D.,
Mummery, C.,
Walker, Z.,
Hoe, J.,
Sampson, E. L.,
Cooper, C.
Objective: To assess whether a manual based coping strategy compared with treatment as usual reduces depression and anxiety symptoms in carers of family members with dementia.; Design: Randomised, parallel group, superiority trial.; Setting: Three mental health community services and one neurological outpatient dementia service in London and Essex, UK.; Participants: 260 carers of family members […]
Learning opportunities in a residential aged care facility: the role of supported placements for first-year nursing students
Lea, Emma,
Marlow, Annette,
Bramble, Marguerite,
Andrews, Sharon,
Crisp, Elaine,
Eccleston, Claire,
Mason, Ron,
Robinson, Andrew
The residential aged care sector is reportedly a less attractive career choice for nursing students than other sectors. Research shows that students are often fearful of working with residents with dementia when they are inadequately supported on clinical placements by aged care staff. Thirty first-year nursing students attended a 2-week placement in one of two […]
Comparison of two analytical platforms for the clinical qualification of Alzheimer’s disease biomarkers in pathologically-confirmed dementia
Le Bastard, Nathalie,
Coart, Els,
Vanderstichele, Hugo,
Vanmechelen, Eugeen,
Martin, Jean-Jacques,
Engelborghs, Sebastiaan
Combined analysis of the Alzheimer’s disease (AD) biomarkers amyloid-β(1-42) (Aβ(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests […]