This database contains 477 studies, archived under the term: "Non-pharmacological Treatment"
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Effects of aerobic exercise on mild cognitive impairment: a controlled trial
Baker, Laura D.,
Frank, Laura L.,
Foster-Schubert, Karen,
Green, Pattie S.,
Wilkinson, Charles W.,
McTiernan, Anne,
Plymate, Stephen R.,
Fishel, Mark A.,
Watson, G. Stennis,
Cholerton, Brenna A.,
Duncan, Glen E.,
Mehta, Pankaj D.,
Craft, Suzanne
Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response.; Design: Six-month, randomized, controlled, clinical trial.; Setting: Veterans Affairs Puget Sound Health Care System clinical research unit.; Participants: Thirty-three […]
Promotion of the mind through exercise (PROMoTE): a proof-of-concept randomized controlled trial of aerobic exercise training in older adults with vascular cognitive impairment
Liu-Ambrose, Teresa,
Eng, Janice J.,
Boyd, Lara A.,
Jacova, Claudia,
Davis, Jennifer C.,
Bryan, Stirling,
Lee, Philip,
Brasher, Penny,
Hsiung, Ging-Yuek R.
Background: Sub-cortical vascular ischaemia is the second most common etiology contributing to cognitive impairment in older adults, and is frequently under-diagnosed and under-treated. Although evidence is mounting that exercise has benefits for cognitive function among seniors, very few randomized controlled trials of exercise have been conducted in populations at high-risk for progression to dementia. Aerobic-based […]
The fitness for the Ageing Brain Study II (FABS II): protocol for a randomized controlled clinical trial evaluating the effect of physical activity on cognitive function in patients with Alzheimer’s disease
Cyarto, Elizabeth V.,
Cox, Kay L.,
Almeida, Osvaldo P.,
Flicker, Leon,
Ames, David,
Byrne, Gerard,
Hill, Keith D.,
Beer, Christopher D.,
LoGiudice, Dina,
Appadurai, Kana,
Irish, Muireann,
Renehan, Emma,
Lautenschlager, Nicola T.
Background: Observational studies have documented a potential protective effect of physical exercise in older adults who are at risk for developing Alzheimer’s disease. The Fitness for the Ageing Brain II (FABS II) study is a multicentre randomized controlled clinical trial (RCT) aiming to determine whether physical activity reduces the rate of cognitive decline among individuals […]
Evaluation of exercise on individuals with dementia and their carers: a randomised controlled trial
Cerga-Pashoja, Arlinda,
Lowery, David,
Bhattacharya, Rahul,
Griffin, Mark,
Iliffe, Steve,
Lee, James,
Leonard, Claire,
Ricketts, Sue,
Strother, Lyn,
Waters, Fiona,
Ritchie, Craig W.,
Warner, James
Background: Almost all of the 820,000 people in the UK with dementia will experience Behavioural and Psychological Symptoms of Dementia (BPSD). However, research has traditionally focused on treating cognitive symptoms, thus neglecting core clinical symptoms that often have a more profound impact on living with dementia. Recent evidence (Kales et al, 2007; Ballard et al, […]
Snoezelen, structured reminiscence therapy and 10-minutes activation in long term care residents with dementia (WISDE): study protocol of a cluster randomized controlled trial
Berg, Almuth,
Sadowski, Katharina,
Beyrodt, Melanie,
Hanns, Stephanie,
Zimmermann, Markus,
Langer, Gero,
Becker, Christiane,
Lautenschläger, Christine,
Behrens, Johann
Background: People with dementia are often inapproachable due to symptoms of their illness. Therefore nurses should establish relationships with dementia patients via their remaining resources and facilitate communication. In order to achieve this, different targeted non-pharmacological interventions are recommended and practiced. However there is no sufficient evidence about the efficacy of most of these interventions. […]
Health and nutritional promotion program for patients with dementia (NutriAlz Study): design and baseline data
Salva, A.,
Andrieu, S.,
Fernandez, E.,
Schiffrin, E. J.,
Moulin, J.,
Decarli, B.,
Guigoz, Y.,
Vellas, B.
Background: There is a lack of data on global weight loss prevention programs for patients with dementia or clear evidence about their impact on a functional level, caregiver burden or the use of healthcare and social resources. NutriAlz is a socio-educative and nutritional intervention program to prevent weight loss and loss of function in dementia […]
Cost-effectiveness of post-diagnosis treatment in dementia coordinated by Multidisciplinary Memory Clinics in comparison to treatment coordinated by general practitioners: an example of a pragmatic trial
Meeuwsen, E. J.,
German, P.,
Melis, R. J. F.,
Adang, E. M.,
Golüke-Willemse, G. A.,
Krabbe, P. F.,
de Leest, B. J.,
van Raak, F. H. J. M.,
Schölzel-Dorenbos, C. J. M.,
Visser, M. C.,
Wolfs, C. A.,
Vliek, S.,
Rikkert, M. G. M. Olde
Background: With the rising number of dementia patients with associated costs and the recognition that there is room for improvement in the provision of dementia care, the question arises on how to efficiently provide high quality dementia care.; Objective: To describe the design of a study to determine multidisciplinary memory clinics’ (MMC) effectiveness and cost-effectiveness […]
Methodological issues in the non pharmacological treatment of BPSD in nursing home–the TNM study
Behavioural and psychological symptoms of dementia (BPSD) such as agitation, aggressiveness, oppositional behaviour and psychotic symptoms are often reported by caregivers and staff members in institutions for the elderly. Taking into account the limited efficacy and the importance of side effects observed with psychotropic agents, the majority of existing guideline underlines the importance of non-pharmacological […]