This database contains 438 studies, archived under the term: "USA"
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Effects of a controlled trial of aerobic exercise for mild cognitive impairment: A controlled trial
Baker, Laura D.,
Frank, Laura L.,
Foster-Schubert, Karen,
Green, Pattie S.,
Wilkinson, Charles W.,
McTiernan, Anne,
Plymate, Stephen R.,
Fishel, Mark A.,
Watson, G. Stennis,
Cholerton, Brenna A.,
Dunca, Glen E.,
Mehta, Pankaj D.,
Craft, Suzanne
Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. Design: Six-month, randomized, controlled, clinical trial. Setting: Veterans Affairs Puget Sound Health Care System clinical research unit. Participants: Thirty-three […]
Diuretic use is associated with better learning and memory in older adults in the Ginkgo Evaluation of Memory Study
Yasar, Sevil,
Lin, Fu-Mei,
Fried, Linda P.,
Kawas, Claudia H.,
Sink, Kaycee M.,
DeKosky, Steven T.,
Carlson, Michelle C.
Background: To investigate the association between diuretics, angiotensin-converting enzyme inhibitors (ACE-I), angiotensin II receptor blockers (AT2RB), and cognitive function.; Methods: This post hoc analysis of the randomized controlled Ginkgo Evaluation of Memory Study trial focuses on 3069 nondemented community-dwelling participants aged >75 years. At baseline visit, detailed information about medication use was collected and five […]
Differences in verbal memory performance in postmenopausal women receiving hormone therapy: 17β-estradiol versus conjugated equine estrogens
Wroolie, Tonita E.,
Kenna, Heather A.,
Williams, Katherine E.,
Powers, Bevin N.,
Holcomb, Megan,
Khaylis, Anna,
Rasgon, Natalie L.
Objective: Much controversy exists and many questions remain unanswered about the effects of hormone therapy (HT) on cognition in postmenopausal women. There is growing evidence suggesting that HT compounds containing conjugated equine estrogen (CEE) have negative effects on cognition whereas 17β-estradiol (17β-E) either has positive or neutral effects. The present study sought to further examine […]
The effects of ramipril in individuals at risk for Alzheimer’s disease: results of a pilot clinical trial
Wharton, Whitney,
Stein, James H.,
Korcarz, Claudia,
Sachs, Jane,
Olson, Sandra R.,
Zetterberg, Henrik,
Dowling, Maritza,
Ye, Shuyun,
Gleason, Carey E.,
Underbakke, Gail,
Jacobson, Laura E.,
Johnson, Sterling C.,
Sager, Mark A.,
Asthana, Sanjay,
Carlsson, Cynthia M.
Research shows that certain antihypertensives taken during midlife confer Alzheimer’s disease (AD) related benefits in later life. We conducted a clinical trial to evaluate the extent to which the angiotensin converting enzyme inhibitor (ACE-I), ramipril, affects AD biomarkers including cerebrospinal fluid (CSF) amyloid-β (Aβ) levels and ACE activity, arterial function, and cognition in participants with […]
Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes
Weaver, Frances M.,
Follett, Kenneth A.,
Stern, Matthew,
Luo, Ping,
Harris, Crystal L.,
Hur, Kwan,
Marks, William J., Jr.,
Rothlind, Johannes,
Sagher, Oren,
Moy, Claudia,
Pahwa, Rajesh,
Burchiel, Kim,
Hogarth, Penelope,
Lai, Eugene C.,
Duda, John E.,
Holloway, Kathryn,
Samii, Ali,
Horn, Stacy,
Bronstein, Jeff M.,
Stoner, Gatana,
Starr, Philip A.,
Simpson, Richard,
Baltuch, Gordon,
De Salles, Antonio,
Huang, Grant D.,
Reda, Domenic J.
Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]
A community-based approach to trials of aerobic exercise in aging and Alzheimer’s disease
Vidoni, Eric D.,
Van Sciver, Angela,
Johnson, David K.,
He, Jinghua,
Honea, Robyn,
Haines, Brian,
Goodwin, Jami,
Laubinger, M. Pat,
Anderson, Heather S.,
Kluding, Patricia M.,
Donnelly, Joseph E.,
Billinger, Sandra A.,
Burns, Jeffrey M.
The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. […]
Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease
Uenaka, Kazunori,
Nakano, Masako,
Willis, Brian A.,
Friedrich, Stuart,
Ferguson-Sells, Lisa,
Dean, Robert A.,
Ieiri, Ichiro,
Siemers, Eric R.
Objectives: Solanezumab is a humanized anti-amyloid β monoclonal antibody being developed as a passive immunization treatment to slow the progression of Alzheimer disease (AD). Pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after a single dose of solanezumab were compared between Japanese and white patients with AD.; Methods: Japanese and white patients with mild to moderate AD […]