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Acute caffeine administration effect on brain activation patterns in mild cognitive impairment


Haller, Sven, Montandon, Marie-Louise, Rodriguez, Cristelle, Moser, Dominik, Toma, Simona, Hofmeister, Jeremy, Sinanaj, Indrit, Lovblad, Karl-Olof, Giannakopoulos, Panteleimon


Journal Of Alzheimer's Disease: JAD, Volume: 41, No.: 1, Pages.: 101-112

Year of Publication



Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in 17 individuals with mild cognitive impairment (MCI) compared to 17 age-matched healthy controls (HC). All individuals were regular caffeine consumers with an overnight abstinence and given 200 mg caffeine versus placebo tablets 30 minutes before testing. Analyses included assessment of task-related activation (general linear model), functional connectivity (tensorial-independent component analysis, TICA), baseline perfusion (arterial spin labeling, ASL), grey matter density (voxel-based morphometry, VBM), and white matter microstructure (tract-based spatial statistics, TBSS). Acute caffeine administration induced a focal activation of the prefrontal areas in HC with a more diffuse and posteromedial activation pattern in MCI individuals. In MCI, TICA documented a significant caffeine-related enhancement in the prefrontal cortex, supplementary motor area, ventral premotor and parietal cortex as well as the basal ganglia and cerebellum. The absence of significant group differences in baseline ASL perfusion patterns supports a neuronal rather than a purely vascular origin of these differences. The VBM and TBSS analyses excluded potentially confounding differences in grey matter density and white matter microstructure between MCI and HC. The present findings suggest a posterior displacement of working memory-related brain activation patterns after caffeine administration in MCI that may represent a compensatory mechanism to counterbalance a frontal lobe dysfunction.;


activation, aged, blood oxygenation level dependent, brain, brain mapping, caffeine, central nervous system stimulants, cerebrovascular circulation, diffusion tensor imaging, drug effects, drug therapy, female, functional magnetic resonance imaging, gray matter, humans, magnetic resonance imaging, male, mild cognitive impairment, neural pathways, neuropsychological tests, pathology, pharmacology, physiology, physiopathology, reaction time, white matter

Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements