Frakey, Laura L., Salloway, Stephen, Buelow, Melissa, Malloy, Paul

Objective: This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs), and caregiver burden in individuals with Alzheimer’s disease (AD).; Method: 23 participants with a diagnosis of mild-to-moderate probable AD according to National Institute of Neurologic and Communicative Disorder and Stroke-Alzheimer’s Disease and Related Disorders criteria were randomized […]

Haller, Sven, Montandon, Marie-Louise, Rodriguez, Cristelle, Moser, Dominik, Toma, Simona, Hofmeister, Jeremy, Sinanaj, Indrit, Lovblad, Karl-Olof, Giannakopoulos, Panteleimon

Previous studies showed that acute caffeine administration enhances task-related brain activation in elderly individuals with preserved cognition. To explore the effects of this widely used agent on cognition and brain activation in early phases of cognitive decline, we performed a double-blinded, placebo-controlled functional magnetic resonance imaging (fMRI) study during an n-back working memory task in […]

Mikhaĭlova, N. M., Selezneva, N. D., Kalyn, Ia B., Roshchina, I. F., Gavrilova, S. I.

Efficacy of actovegin was investigated in the treatment of mild cognitive impairment (MCI) of cerebrovascular genesis. Thirty patients (7 men and 23 women, mean age 71.2 years) received actovegin intramuscularly in dosage 5 ml (200 mg) daily during 4 weeks. Patient’s were assessed before and after treatment using CGI and MMSE, verbal association test, scale […]

Lanctôt, Krista L., Chau, Sarah A., Herrmann, Nathan, Drye, Lea T., Rosenberg, Paul B., Scherer, Roberta W., Black, Sandra E., Vaidya, Vijay, Bachman, David L., Mintzer, Jacobo E.

Background: Little is known about the effect of methylphenidate (MPH) on attention in Alzheimer’s disease (AD). MPH has shown to improve apathy in AD, and both apathy and attention have been related to dopaminergic function. The goal was to investigate MPH effects on attention in AD and assess the relationship between attention and apathy responses.; […]