This database contains 664 studies, archived under the term: "Randomised Controlled Trial"
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Effects of a low-volume, nutrient- and energy-dense oral nutritional supplement on nutritional and functional status: a randomized, controlled trial in nursing home residents
Stange, Inken,
Bartram, Matthias,
Liao, Yuye,
Poeschl, Karin,
Kolpatzik, Sarah,
Uter, Wolfgang,
Sieber, Cornel C.,
Stehle, Peter,
Volkert, Dorothee
Objectives: Although oral nutritional supplements (ONS) are known to be effective to treat malnutrition in the elderly, evidence from nursing home populations, including individuals with dementia, is rare, especially with regard to functionality and well-being. A known barrier for ONS use among elderly is the volume that needs to be consumed, resulting in low compliance […]
One-year safety and tolerability profile of pridopidine in patients with Huntington disease
Squitieri, Ferdinando,
Landwehrmeyer, Bernhard,
Reilmann, Ralf,
Rosser, Anne,
de Yebenes, Justo Garcia,
Prang, Allan,
Ivkovic, Jelena,
Bright, Jeremy,
Rembratt, Åsa
Objective: To assess the 1-year safety profile of the dopaminergic stabilizer pridopidine in patients with Huntington disease. Methods: Patients received pridopidine 45 mg/day for 4 weeks then pridopidine 90 mg/day for 22 weeks in this 6-month open-label extension (OLE) of the 6-month MermaiHD randomized controlled trial (RCT). Any adverse events (AEs) were recorded. Patients were […]
Influence of adherence to a systematic care program for caregivers of dementia patients
Spijker, Anouk,
Teerenstra, Steven,
Wollersheim, Hub,
Adang, Eddy,
Verhey, Frans,
Vernooij-Dassen, Myrra
Objective: To evaluate the influence of adherence to the Systematic Care Program for Dementia (SCPD) intervention protocol on patient and caregiver outcomes.; Design: Data were drawn from the SCPD study-a single-blind, multicenter, cluster-randomized, controlled trial. Multivariate regression analyses were used to assess the influence of adherence on patient and caregiver outcomes.; Setting: Six community mental health […]
CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans
Spies, Petra E.,
Slats, Diane,
Olde Rikkert, Marcel G. M.,
Tseng, Jack,
Claassen, Jurgen A. H. R.,
Verbeek, Marcel M.
Reports on the value of cerebrospinal fluid (CSF) α-synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF α-synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid β concentrations. Furthermore, a physiological relationship between α-synuclein and amyloid β has been suggested […]
Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer’s disease
Solé-Padullés, Cristina,
Bartrés-Faz, David,
Lladó, Albert,
Bosch, Beatriz,
Peña-Gómez, Cleofé,
Castellví, Magdalena,
Rami, Lorena,
Bargalló, Nuria,
Sánchez-Valle, Raquel,
Molinuevo, José Luis
Previous studies with functional magnetic resonance imaging (fMRI) demonstrated a differential brain activity and connectivity after treatment with donepezil in Alzheimer’s disease (AD) when compared to healthy elders. Importantly however, there are no available studies where the placebo or control group included comparable AD patients relative to the treated groups. Fifteen patients recently diagnosed of […]
Cost analysis of early psychosocial intervention in Alzheimer’s disease
Søgaard, Rikke,
Sørensen, Jan,
Waldorff, Frans B.,
Eckermann, Ane,
Buss, Dorthe V.,
Waldemar, Gunhild
Background/aim: To investigate the impact of early psychosocial intervention aimed at patients with Alzheimer’s disease (AD) and their caregivers on resource use and costs from a societal perspective.; Methods: Dyads of patients and their primary caregiver were randomised to intervention (n = 163) or control (n = 167) and followed for 3 years. Health care […]
Alzheimer’s disease (AD) and executive dysfunction. A case-control study on the significance of frontal white matter changes detected by diffusion tensor imaging (DTI)
Sjöbeck, Martin,
Elfgren, Christina,
Larsson, Elna-Marie,
Brockstedt, Sara,
Lätt, Jimmy,
Englund, Elisabet,
Passant, Ulla
White matter (WM) changes are frequently seen on structural imaging in AD but the clinical relevance of these changes is uncertain. Frontal WM pathology is often observed upon neuropathological examination in AD. Since frontal cortical/sub-cortical pathology is known to relate to executive dysfunction, the aim was to elucidate if frontal WM changes in AD correlated […]
Rivastigmine for HIV-associated neurocognitive disorders: a randomized crossover pilot study
Simioni, S.,
Cavassini, M.,
Annoni, J.-M.,
Metral, M.,
Iglesias, K.,
Rimbault Abraham, A.,
Jilek, S.,
Calmy, A.,
Muller, H.,
Fayet-Mello, A.,
Giacobini, E.,
Hirschel, B.,
Du Pasquier, R. A.
Objective: To assess the efficacy and safety of rivastigmine for the treatment of HIV-associated neurocognitive disorders (HAND) in a cohort of long-lasting aviremic HIV+ patients.; Methods: Seventeen aviremic HIV+ patients with HAND were enrolled in a randomized, double-blind, placebo-controlled, crossover study to receive either oral rivastigmine (up to 12 mg/day for 20 weeks) followed by […]