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Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer’s disease


Solé-Padullés, Cristina, Bartrés-Faz, David, Lladó, Albert, Bosch, Beatriz, Peña-Gómez, Cleofé, Castellví, Magdalena, Rami, Lorena, Bargalló, Nuria, Sánchez-Valle, Raquel, Molinuevo, José Luis


Journal Of Clinical Psychopharmacology, Volume: 33, No.: 2, Pages.: 199-205

Year of Publication



Previous studies with functional magnetic resonance imaging (fMRI) demonstrated a differential brain activity and connectivity after treatment with donepezil in Alzheimer’s disease (AD) when compared to healthy elders. Importantly however, there are no available studies where the placebo or control group included comparable AD patients relative to the treated groups. Fifteen patients recently diagnosed of AD were randomized to treatment (n = 8) or to control group (n = 7); the former receiving daily treatment of donepezil during 3 months. At baseline and follow-up, both groups underwent resting-state as well as task-fMRI examinations, this latter assessing encoding of visual scenes. The treated group showed higher connectivity in areas of the default mode network, namely the right parahippocampal gyrus at follow-up resting-fMRI as compared to the control group. On the other hand, for the task-fMRI, the untreated AD group presented progressive increased activation in the left middle temporal gyrus and bilateral precuneus at the 3-month examination compared to baseline, whereas the treated group exhibited stable patterns of brain activity. Donepezil treatment is associated with stabilization of connectivity of medial temporal regions during resting state and of brain efficiency during a cognitive demand, on the whole reducing progressive dysfunctional reorganizations observed during the natural course of the disease.;

Bibtex Citation

@article{Sol_Padull_s_2013, doi = {10.1097/jcp.0b013e3182825bfd}, url = {}, year = 2013, month = {apr}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {33}, number = {2}, pages = {199--205}, author = {Cristina Sol{'{e}}-Padull{'{e}}s and David Bartr{'{e}}s-Faz and Albert Llad{'{o}} and Beatriz Bosch and Cleof{'{e}} Pe{~{n}}a-G{'{o}}mez and Magdalena Castellv{'{i}} and Lorena Rami and Nuria Bargall{'{o}} and Raquel S{'{a}}nchez-Valle and Jos{'{e}} Luis Molinuevo}, title = {Donepezil Treatment Stabilizes Functional Connectivity During Resting State and Brain Activity During Memory Encoding in Alzheimer's Disease}, journal = {Journal of Clinical Psychopharmacology} }


aged, aged, 80 and over, alzheimer disease, brain, cholinesterase inhibitors, donepezil, drug effects, drug therapy, female, humans, indans, magnetic resonance imaging, memory, pharmacology, physiopathology, piperidines, time factors

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime